Cargando…

LGR5 expression is associated with prognosis in poorly differentiated gastric adenocarcinoma

BACKGROUND: Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is an important cancer stem cell marker in gastric cancer. However, no detailed studies are available on LGR5 expression in poorly differentiated gastric adenocarcinoma (PD-AC). Therefore, we investigated the relationship...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ehara, Takehito, Uehara, Takeshi, Nakajima, Tomoyuki, Kinugawa, Yasuhiro, Kobayashi, Shota, Iwaya, Mai, Ota, Hiroyoshi, Soejima, Yuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936409/ https://www.ncbi.nlm.nih.gov/pubmed/33676447 http://dx.doi.org/10.1186/s12885-021-07913-6

Ejemplares similares

Characterization of LGR5 expression in poorly differentiated colorectal carcinoma with mismatch repair protein deficiency
por: Nakajima, Tomoyuki, et al.
Publicado: (2020)

LGR5 expression and clinicopathological features of the invasive front in the fat infiltration area of pancreatic cancer
por: Kamakura, Masato, et al.
Publicado: (2022)

Most colitis associated carcinomas lack expression of LGR5: a preliminary study with implications for unique pathways of carcinogenesis compared to sporadic colorectal carcinoma
por: Iwaya, Mai, et al.
Publicado: (2021)

IL-6 expression helps distinguish Castleman’s disease from IgG4-related disease in the lung
por: Kinugawa, Yasuhiro, et al.
Publicado: (2021)

ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer
por: Kanai, Ryo, et al.
Publicado: (2023)

Alpha-Fetoprotein-Producing Early Gastric Cancer with Intramucosal Hepatoid and Fetal Enteric Differentiation
por: Iwaya, Mai, et al.
Publicado: (2020)

Impact of DNA double-strand breaks on pancreaticobiliary maljunction carcinogenesis
por: Kuraishi, Yasuhiro, et al.
Publicado: (2021)

Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine
por: Daikuhara, Seiichi, et al.
Publicado: (2015)

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma
por: Mizuno, Nobumasa, et al.
Publicado: (2013)

Association of Serum Creatinine Level with Prognosis of Laparotomy for Acute Mesenteric Ischemia after Cardiovascular Surgery
por: Miyagawa, Yusuke, et al.
Publicado: (2022)

A case of appendiceal ganglioneuroma in neurofibromatosis type 1
por: Shimizu, Tadaaki, et al.
Publicado: (2021)

Hereditary diffuse gastric cancer in a Japanese family with CDH1 mutation three case reports
por: Muranaka, Futoshi, et al.
Publicado: (2023)

Gastric adenocarcinoma arising from hamartomatous inverted polyp during 8‐year follow‐up
por: Okamura, Takuma, et al.
Publicado: (2021)

LGR5 Expression Predicting Poor Prognosis Is Negatively Correlated with WNT5A in Colon Cancer
por: Mehdawi, Lubna M., et al.
Publicado: (2023)

Regulatory T Cells Promote Overexpression of Lgr5 on Gastric Cancer Cells via TGF-beta1 and Confer Poor Prognosis in Gastric Cancer
por: Liu, Xiao-Sun, et al.
Publicado: (2019)

Association of Daily Variance in Air Temperature With Postoperative Adhesive Small Bowel Obstruction
por: Yamamoto, Yuta, et al.
Publicado: (2022)

Poor Prognosis of Gastric Adenocarcinoma with Decreased Expression of AHRR
por: Li, Yuan-fang, et al.
Publicado: (2012)

Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma
por: Jin, Jingchun, et al.
Publicado: (2012)

Increased PD-1-positive macrophages in the tissue of gastric cancer are closely associated with poor prognosis in gastric cancer patients
por: Kono, Yusuke, et al.
Publicado: (2020)

Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma
por: Ko, Chih-Jan, et al.
Publicado: (2019)

LGR5 and LGR6 in stem cell biology and ovarian cancer
por: Schindler, Adam J., et al.
Publicado: (2017)

LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway
por: Wang, Xiangfei, et al.
Publicado: (2018)

High expression of DEK predicts poor prognosis of gastric adenocarcinoma
por: Piao, Junjie, et al.
Publicado: (2014)

Reduced Expression of PTPRD Correlates with Poor Prognosis in Gastric Adenocarcinoma
por: Wang, Dandan, et al.
Publicado: (2014)

Lgr5-positive cells in the lung and their clinical significance in patients with lung adenocarcinoma
por: Zhang, Xiaohan, et al.
Publicado: (2016)

LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation
por: Tsai, Yu-Hwai, et al.
Publicado: (2016)

Correction: LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway
por: Wang, Xiangfei, et al.
Publicado: (2019)

LGR5 overexpression confers poor relapse-free survival in breast cancer patients
por: Hou, Ming-Feng, et al.
Publicado: (2018)

Reduced Expression of Uroplakin 1A Is Associated with the Poor Prognosis of Gastric Adenocarcinoma Patients
por: Zheng, Yan, et al.
Publicado: (2014)

Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6
por: Lee, Joo-Hyeon, et al.
Publicado: (2017)

Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma
por: Yamakawa, Kohei, et al.
Publicado: (2022)

Lgr5 Methylation in Cancer Stem Cell Differentiation and Prognosis-Prediction in Colorectal Cancer
por: Su, Shasha, et al.
Publicado: (2015)

Impact of seasonal and meteorological factors on the incidence of adhesive small bowel obstruction: A large‐scale study using a national inpatient database
por: Yamamoto, Yuta, et al.
Publicado: (2021)

RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer
por: Nakamura, Satoshi, et al.
Publicado: (2023)

Elevated expression of Nodal and YAP1 is associated with poor prognosis of gastric adenocarcinoma
por: Li, Ping, et al.
Publicado: (2016)

CREM Is Correlated With Immune-Suppressive Microenvironment and Predicts Poor Prognosis in Gastric Adenocarcinoma
por: Yu, Kuai, et al.
Publicado: (2021)

Increased oxidative stress during exercise predicts poor prognosis in patients with acute decompensated heart failure
por: Shibata, Atsushi, et al.
Publicado: (2021)

LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea
por: Żak, Magdalena, et al.
Publicado: (2016)

Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea
por: Cheng, Cheng, et al.
Publicado: (2017)

LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43/ZNRF3 to provide high affinity binding of R-spondin ligands
por: Toh, Yukimatsu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a682v5r8grs05s17knkmck34bn