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Carbon Nanotubes: Smart Drug/Gene Delivery Carriers
The unique properties of carbon nanotubes (CNTs) (such as their high surface to volume ratios, enhanced conductivity and strength, biocompatibility, ease of functionalization, optical properties, etc.) have led to their consideration to serve as novel drug and gene delivery carriers. CNTs are effect...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936533/ https://www.ncbi.nlm.nih.gov/pubmed/33688185 http://dx.doi.org/10.2147/IJN.S299448 |
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author | Zare, Hossein Ahmadi, Sepideh Ghasemi, Amir Ghanbari, Mohammad Rabiee, Navid Bagherzadeh, Mojtaba Karimi, Mahdi Webster, Thomas J Hamblin, Michael R Mostafavi, Ebrahim |
author_facet | Zare, Hossein Ahmadi, Sepideh Ghasemi, Amir Ghanbari, Mohammad Rabiee, Navid Bagherzadeh, Mojtaba Karimi, Mahdi Webster, Thomas J Hamblin, Michael R Mostafavi, Ebrahim |
author_sort | Zare, Hossein |
collection | PubMed |
description | The unique properties of carbon nanotubes (CNTs) (such as their high surface to volume ratios, enhanced conductivity and strength, biocompatibility, ease of functionalization, optical properties, etc.) have led to their consideration to serve as novel drug and gene delivery carriers. CNTs are effectively taken up by many different cell types through several mechanisms. CNTs have acted as carriers of anticancer molecules (including docetaxel (DTX), doxorubicin (DOX), methotrexate (MTX), paclitaxel (PTX), and gemcitabine (GEM)), anti-inflammatory drugs, osteogenic dexamethasone (DEX) steroids, etc. In addition, the unique optical properties of CNTs have led to their use in a number of platforms for improved photo-therapy. Further, the easy surface functionalization of CNTs has prompted their use to deliver different genes, such as plasmid DNA (PDNA), micro-RNA (miRNA), and small interfering RNA (siRNA) as gene delivery vectors for various diseases such as cancers. However, despite all of these promises, the most important continuous concerns raised by scientists reside in CNT nanotoxicology and the environmental effects of CNTs, mostly because of their non-biodegradable state. Despite a lack of widespread FDA approval, CNTs have been studied for decades and plenty of in vivo and in vitro reports have been published, which are reviewed here. Lastly, this review covers the future research necessary for the field of CNT medicine to grow even further. |
format | Online Article Text |
id | pubmed-7936533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-79365332021-03-08 Carbon Nanotubes: Smart Drug/Gene Delivery Carriers Zare, Hossein Ahmadi, Sepideh Ghasemi, Amir Ghanbari, Mohammad Rabiee, Navid Bagherzadeh, Mojtaba Karimi, Mahdi Webster, Thomas J Hamblin, Michael R Mostafavi, Ebrahim Int J Nanomedicine Review The unique properties of carbon nanotubes (CNTs) (such as their high surface to volume ratios, enhanced conductivity and strength, biocompatibility, ease of functionalization, optical properties, etc.) have led to their consideration to serve as novel drug and gene delivery carriers. CNTs are effectively taken up by many different cell types through several mechanisms. CNTs have acted as carriers of anticancer molecules (including docetaxel (DTX), doxorubicin (DOX), methotrexate (MTX), paclitaxel (PTX), and gemcitabine (GEM)), anti-inflammatory drugs, osteogenic dexamethasone (DEX) steroids, etc. In addition, the unique optical properties of CNTs have led to their use in a number of platforms for improved photo-therapy. Further, the easy surface functionalization of CNTs has prompted their use to deliver different genes, such as plasmid DNA (PDNA), micro-RNA (miRNA), and small interfering RNA (siRNA) as gene delivery vectors for various diseases such as cancers. However, despite all of these promises, the most important continuous concerns raised by scientists reside in CNT nanotoxicology and the environmental effects of CNTs, mostly because of their non-biodegradable state. Despite a lack of widespread FDA approval, CNTs have been studied for decades and plenty of in vivo and in vitro reports have been published, which are reviewed here. Lastly, this review covers the future research necessary for the field of CNT medicine to grow even further. Dove 2021-03-01 /pmc/articles/PMC7936533/ /pubmed/33688185 http://dx.doi.org/10.2147/IJN.S299448 Text en © 2021 Zare et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Zare, Hossein Ahmadi, Sepideh Ghasemi, Amir Ghanbari, Mohammad Rabiee, Navid Bagherzadeh, Mojtaba Karimi, Mahdi Webster, Thomas J Hamblin, Michael R Mostafavi, Ebrahim Carbon Nanotubes: Smart Drug/Gene Delivery Carriers |
title | Carbon Nanotubes: Smart Drug/Gene Delivery Carriers |
title_full | Carbon Nanotubes: Smart Drug/Gene Delivery Carriers |
title_fullStr | Carbon Nanotubes: Smart Drug/Gene Delivery Carriers |
title_full_unstemmed | Carbon Nanotubes: Smart Drug/Gene Delivery Carriers |
title_short | Carbon Nanotubes: Smart Drug/Gene Delivery Carriers |
title_sort | carbon nanotubes: smart drug/gene delivery carriers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936533/ https://www.ncbi.nlm.nih.gov/pubmed/33688185 http://dx.doi.org/10.2147/IJN.S299448 |
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