Cargando…

Exploring naphthyl derivatives as SARS-CoV papain-like protease (PLpro) inhibitors and its implications in COVID-19 drug discovery

ABSTRACT: Novel coronavirus disease 2019 (COVID-19) emerges as a serious threat to public health globally. The rapid spreading of COVID-19, caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), proclaimed the multitude of applied research needed not only to save the human he...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amin, Sk. Abdul, Ghosh, Kalyan, Singh, Samayaditya, Qureshi, Insaf Ahmed, Jha, Tarun, Gayen, Shovanlal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936608/ https://www.ncbi.nlm.nih.gov/pubmed/33675510 http://dx.doi.org/10.1007/s11030-021-10198-3

Ejemplares similares

Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors
por: Amin, Sk. Abdul, et al.
Publicado: (2021)

First structure–activity relationship analysis of SARS-CoV-2 virus main protease (Mpro) inhibitors: an endeavor on COVID-19 drug discovery
por: Amin, Sk. Abdul, et al.
Publicado: (2021)

Unmasking of crucial structural fragments for coronavirus protease inhibitors and its implications in COVID-19 drug discovery
por: Ghosh, Kalyan, et al.
Publicado: (2021)

Chemical-informatics approach to COVID-19 drug discovery: Exploration of important fragments and data mining based prediction of some hits from natural origins as main protease (Mpro) inhibitors
por: Ghosh, Kalyan, et al.
Publicado: (2021)

Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors?
por: Amin, Sk Abdul, et al.
Publicado: (2021)

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
por: Klemm, Theresa, et al.
Publicado: (2020)

Genetically Encoded Fluorescent Sensors for SARS-CoV-2 Papain-like Protease PLpro
por: Sokolinskaya, Elena L., et al.
Publicado: (2022)

Identification of SARS‐CoV‐2 Papain‐like Protease (PLpro) Inhibitors Using Combined Computational Approach
por: Sencanski, Milan, et al.
Publicado: (2022)

Association between Mutations in Papain-like Protease (PLpro) of SARS-CoV-2 with COVID-19 Clinical Outcomes
por: Tan, Jinlin, et al.
Publicado: (2022)

Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity
por: Kawall, Anasha, et al.
Publicado: (2023)

SARS-COV-2 Coronavirus Papain-like Protease PLpro as an Antiviral Target for Inhibitors of Active Site and Protein–Protein Interactions
por: Ershov, P. V., et al.
Publicado: (2023)

Screening and identification of potential MERS-CoV papain-like protease (PLpro) inhibitors; Steady-state kinetic and Molecular dynamic studies
por: Ali Dahhas, Mohammed, et al.
Publicado: (2023)

Molecular dynamics analysis of phytochemicals from Ageratina adenophora against COVID-19 main protease (M(pro)) and human angiotensin-converting enzyme 2 (ACE2)
por: Neupane, Netra Prasad, et al.
Publicado: (2021)

Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro
por: Lewis, Devin S. M., et al.
Publicado: (2022)

Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication
por: Bajaj, Teena, et al.
Publicado: (2023)

Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease
por: Mirza, Muhammad Usman, et al.
Publicado: (2020)

Discovery of novel papain-like protease inhibitors for potential treatment of COVID-19
por: Hersi, Fatema, et al.
Publicado: (2023)

Computational study of the binding orientation and affinity of noncovalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-1 considering the protein flexibility by using molecular dynamics and cross-docking
por: Castillo-Campos, Luis, et al.
Publicado: (2023)

Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches
por: Alamri, Mubarak A., et al.
Publicado: (2020)

In silico Exploration of Inhibitors for SARS-CoV-2's Papain-Like Protease
por: Huynh, Tien, et al.
Publicado: (2021)

THE REMOVAL OF CARTILAGE MATRIX, IN VIVO, BY PAPAIN : IDENTIFICATION OF CRYSTALLINE PAPAIN PROTEASE AS THE CAUSE OF THE PHENOMENON
por: McCluskey, Robert T., et al.
Publicado: (1958)

Meticulous assessment of natural compounds from NPASS database for identifying analogue of GRL0617, the only known inhibitor for SARS-CoV2 papain-like protease (PLpro) using rigorous computational workflow
por: Parmar, Paritosh, et al.
Publicado: (2021)

Investigation of the Detailed Internal Structure and Dynamics of Itraconazole by Solid-State NMR Measurements
por: Dey, Krishna Kishor, et al.
Publicado: (2019)

Understanding the correlation between structure and dynamics of clocortolone pivalate by solid state NMR measurement
por: Dey, Krishna Kishor, et al.
Publicado: (2020)

An atomic resolution description of folic acid using solid state NMR measurements
por: Ghosh, Manasi, et al.
Publicado: (2020)

6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities
por: Swaim, Caleb D., et al.
Publicado: (2020)

Identifying structural–functional analogue of GRL0617, the only well-established inhibitor for papain-like protease (PLpro) of SARS-CoV2 from the pool of fungal metabolites using docking and molecular dynamics simulation
por: Rao, Priyashi, et al.
Publicado: (2021)

Supporting SARS-CoV-2 Papain-Like Protease Drug Discovery: In silico Methods and Benchmarking
por: Ibrahim, Tamer M., et al.
Publicado: (2020)

Discovery of the Cryptic Sites of SARS-CoV-2 Papain-like Protease and Analysis of Its Druggability
por: Qiu, Yue, et al.
Publicado: (2022)

Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay
por: Narayanan, Anoop, et al.
Publicado: (2022)

Role of Papain-Like Cysteine Proteases in Plant Development
por: Liu, Huijuan, et al.
Publicado: (2018)

Synergistic Inhibitor Binding to the Papain‐Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications
por: Lee, Hyun, et al.
Publicado: (2013)

Inhibitors of SARS-CoV-2 PLpro
por: Calleja, Dale J., et al.
Publicado: (2022)

The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLpro)—preliminary molecular docking analysis
por: Marciniec, Krzysztof, et al.
Publicado: (2021)

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities
por: Mielech, Anna M., et al.
Publicado: (2014)

Structural and functional characterization of MERS coronavirus papain-like protease
por: Lin, Min-Han, et al.
Publicado: (2014)

Deubiquitinating Activity of the SARS-CoV Papain-Like Protease
por: Barretto, Naina, et al.
Publicado: (2006)

Targeting papain-like protease for broad-spectrum coronavirus inhibition
por: Yuan, Shuofeng, et al.
Publicado: (2022)

Structure determinants defining the specificity of papain-like cysteine proteases
por: Petushkova, Anastasiia I., et al.
Publicado: (2022)

Deciphering the Potential of Pre and Pro-Vitamin D of Mushrooms against Mpro and PLpro Proteases of COVID-19: An In Silico Approach
por: Tiwari, Abhay, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_oe95minkvr6crd8ae133b7pahi