A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

A hallmark of aging is loss of differentiated cell identity. Aged Drosophila midgut differentiated enterocytes (ECs) lose their identity, impairing tissue homeostasis. To discover identity regulators, we performed an RNAi screen targeting ubiquitin-related genes in ECs. Seventeen genes were identifi...

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Detalles Bibliográficos
Autores principales: Erez, Neta, Israitel, Lena, Bitman-Lotan, Eliya, Wong, Wing H, Raz, Gal, Cornelio-Parra, Dayanne V, Danial, Salwa, Flint Brodsly, Na'ama, Belova, Elena, Maksimenko, Oksana, Georgiev, Pavel, Druley, Todd, Mohan, Ryan D, Orian, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936876/
https://www.ncbi.nlm.nih.gov/pubmed/33629655
http://dx.doi.org/10.7554/eLife.62312

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