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Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis

OBJECTIVES: An efficient pharmacological response to MTX treatment in RA patients relies on the retention and accumulation of intracellular MTX-polyglutamates catalysed by the enzyme folylpolyglutamate synthetase (FPGS). We recently identified a partial retention of FPGS intron 8 (8PR) as a prominen...

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Detalles Bibliográficos
Autores principales:	Muller, Ittai B, Lin, Marry, Lems, Willem F, ter Wee, Marieke M, Wojtuszkiewicz, Anna, Nurmohamed, Michael T, Cloos, Jacqueline, Assaraf, Yehuda G, Jansen, Gerrit, de Jonge, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Clinical Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937028/ https://www.ncbi.nlm.nih.gov/pubmed/32940699 http://dx.doi.org/10.1093/rheumatology/keaa428

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