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Typical symptoms of common otorhinolaryngological diseases may mask a SARS-CoV-2 infection
PURPOSE: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) replicates predominantly in the upper respiratory tract and is primarily transmitted by droplets and aerosols. Taking the medical history for typical COVID-19 symptoms and PCR-based SARS-CoV-2 testing have become established...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937047/ https://www.ncbi.nlm.nih.gov/pubmed/33677653 http://dx.doi.org/10.1007/s00405-021-06726-4 |
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author | Weiss, Roxanne Guchlerner, Leon Loth, Andreas G. Leinung, Martin Wicker, Sabine Kempf, Volkhard A. J. Berger, Annemarie Rabenau, Holger F. Ciesek, Sandra Stöver, Timo Diensthuber, Marc |
author_facet | Weiss, Roxanne Guchlerner, Leon Loth, Andreas G. Leinung, Martin Wicker, Sabine Kempf, Volkhard A. J. Berger, Annemarie Rabenau, Holger F. Ciesek, Sandra Stöver, Timo Diensthuber, Marc |
author_sort | Weiss, Roxanne |
collection | PubMed |
description | PURPOSE: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) replicates predominantly in the upper respiratory tract and is primarily transmitted by droplets and aerosols. Taking the medical history for typical COVID-19 symptoms and PCR-based SARS-CoV-2 testing have become established as screening procedures. The aim of this work was to describe the clinical appearance of SARS-CoV-2-PCR positive patients and to determine the SARS-CoV-2 contact risk for health care workers (HCW). METHODS: The retrospective study included n = 2283 SARS-CoV-2 PCR tests from n = 1725 patients with otorhinolaryngological (ORL) diseases performed from March to November 2020 prior to inpatient treatment. In addition, demographic data and medical history were assessed. RESULTS: n = 13 PCR tests (0.6%) were positive for SARS-CoV-2 RNA. The positive rate showed a significant increase during the observation period (p < 0.01). None of the patients had clinical symptoms that led to a suspected diagnosis of COVID-19 before PCR testing. The patients were either asymptomatic (n = 4) or had symptoms that were interpreted as symptoms typical of the ORL disease or secondary diagnoses (n = 9). CONCLUSION: The identification of SARS-CoV-2-positive patients is a considerable challenge in clinical practice. Our findings illustrate that taking a medical history alone is of limited value and cannot replace molecular SARS-CoV-2 testing, especially for patients with ORL diseases. Our data also demonstrate that there is a high probability of contact with SARS-CoV-2-positive patients in everyday clinical practice, so that the use of personal protective equipment, even in apparently “routine cases”, is highly recommended. |
format | Online Article Text |
id | pubmed-7937047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-79370472021-03-08 Typical symptoms of common otorhinolaryngological diseases may mask a SARS-CoV-2 infection Weiss, Roxanne Guchlerner, Leon Loth, Andreas G. Leinung, Martin Wicker, Sabine Kempf, Volkhard A. J. Berger, Annemarie Rabenau, Holger F. Ciesek, Sandra Stöver, Timo Diensthuber, Marc Eur Arch Otorhinolaryngol Miscellaneous PURPOSE: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) replicates predominantly in the upper respiratory tract and is primarily transmitted by droplets and aerosols. Taking the medical history for typical COVID-19 symptoms and PCR-based SARS-CoV-2 testing have become established as screening procedures. The aim of this work was to describe the clinical appearance of SARS-CoV-2-PCR positive patients and to determine the SARS-CoV-2 contact risk for health care workers (HCW). METHODS: The retrospective study included n = 2283 SARS-CoV-2 PCR tests from n = 1725 patients with otorhinolaryngological (ORL) diseases performed from March to November 2020 prior to inpatient treatment. In addition, demographic data and medical history were assessed. RESULTS: n = 13 PCR tests (0.6%) were positive for SARS-CoV-2 RNA. The positive rate showed a significant increase during the observation period (p < 0.01). None of the patients had clinical symptoms that led to a suspected diagnosis of COVID-19 before PCR testing. The patients were either asymptomatic (n = 4) or had symptoms that were interpreted as symptoms typical of the ORL disease or secondary diagnoses (n = 9). CONCLUSION: The identification of SARS-CoV-2-positive patients is a considerable challenge in clinical practice. Our findings illustrate that taking a medical history alone is of limited value and cannot replace molecular SARS-CoV-2 testing, especially for patients with ORL diseases. Our data also demonstrate that there is a high probability of contact with SARS-CoV-2-positive patients in everyday clinical practice, so that the use of personal protective equipment, even in apparently “routine cases”, is highly recommended. Springer Berlin Heidelberg 2021-03-07 2021 /pmc/articles/PMC7937047/ /pubmed/33677653 http://dx.doi.org/10.1007/s00405-021-06726-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Miscellaneous Weiss, Roxanne Guchlerner, Leon Loth, Andreas G. Leinung, Martin Wicker, Sabine Kempf, Volkhard A. J. Berger, Annemarie Rabenau, Holger F. Ciesek, Sandra Stöver, Timo Diensthuber, Marc Typical symptoms of common otorhinolaryngological diseases may mask a SARS-CoV-2 infection |
title | Typical symptoms of common otorhinolaryngological diseases may mask a SARS-CoV-2 infection |
title_full | Typical symptoms of common otorhinolaryngological diseases may mask a SARS-CoV-2 infection |
title_fullStr | Typical symptoms of common otorhinolaryngological diseases may mask a SARS-CoV-2 infection |
title_full_unstemmed | Typical symptoms of common otorhinolaryngological diseases may mask a SARS-CoV-2 infection |
title_short | Typical symptoms of common otorhinolaryngological diseases may mask a SARS-CoV-2 infection |
title_sort | typical symptoms of common otorhinolaryngological diseases may mask a sars-cov-2 infection |
topic | Miscellaneous |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937047/ https://www.ncbi.nlm.nih.gov/pubmed/33677653 http://dx.doi.org/10.1007/s00405-021-06726-4 |
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