Inhibition of ERAD synergizes with FTS to eradicate pancreatic cancer cells

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal cancers, is driven by oncogenic KRAS mutations. Farnesyl thiosalicylic acid (FTS), also known as salirasib, is a RAS inhibitor that selectively dislodges active RAS proteins from cell membrane, inhibiting downstream signalin...

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Detalles Bibliográficos
Autores principales: Du, Rong, Sullivan, Delaney K., Azizian, Nancy G., Liu, Yuanhui, Li, Yulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937230/
https://www.ncbi.nlm.nih.gov/pubmed/33676427
http://dx.doi.org/10.1186/s12885-021-07967-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937230/
https://www.ncbi.nlm.nih.gov/pubmed/33676427
http://dx.doi.org/10.1186/s12885-021-07967-6

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