Protecting P-glycoprotein at the blood–brain barrier from degradation in an Alzheimer’s disease mouse model

BACKGROUND: Failure to clear Aβ from the brain is partly responsible for Aβ brain accumulation in Alzheimer’s disease (AD). A critical protein for clearing Aβ across the blood-brain barrier is the efflux transporter P-glycoprotein (P-gp). In AD, P-gp levels are reduced, which contributes to impaired...

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Detalles Bibliográficos
Autores principales: Ding, Yujie, Zhong, Yu, Baldeshwiler, Andrea, Abner, Erin L., Bauer, Björn, Hartz, Anika M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937299/
https://www.ncbi.nlm.nih.gov/pubmed/33676539
http://dx.doi.org/10.1186/s12987-021-00245-4

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