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Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices

Hepatitis B virus (HBV) still remains a major global public health problem. One-half to one-third of the total HBV infected people died due to late detection of HBV. Serological antigen and viral HBV detections can help in the diagnosis, referral, and treatment of HBV. Available methods for HBV dete...

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Autores principales: Tyas, Aulia A., Raeni, Septi F., Sakti, Setyawan P., Sabarudin, Akhmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937490/
https://www.ncbi.nlm.nih.gov/pubmed/33727897
http://dx.doi.org/10.1155/2021/6643573
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author Tyas, Aulia A.
Raeni, Septi F.
Sakti, Setyawan P.
Sabarudin, Akhmad
author_facet Tyas, Aulia A.
Raeni, Septi F.
Sakti, Setyawan P.
Sabarudin, Akhmad
author_sort Tyas, Aulia A.
collection PubMed
description Hepatitis B virus (HBV) still remains a major global public health problem. One-half to one-third of the total HBV infected people died due to late detection of HBV. Serological antigen and viral HBV detections can help in the diagnosis, referral, and treatment of HBV. Available methods for HBV detection mostly used bulky instruments. Miniaturization of devices for HBV detection has been started by narrowing down the size of the devices. Several methods have also been proposed to increase the selectivity and sensitivity of the miniaturized methods, such as sandwich recognition of the biomarkers and the use of nano- to micro-sized materials. This review presents recent HBV detections in the last two decades from laboratory-based instruments towards microfluidic paper-based analytical devices (µPADs) for point-of-care testing (POCT) purposes. Early and routine analysis to detect HBV as early as possible could be achieved by POCT, especially for areas with limited access to a central laboratory and/or medical facilities.
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spelling pubmed-79374902021-03-15 Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices Tyas, Aulia A. Raeni, Septi F. Sakti, Setyawan P. Sabarudin, Akhmad ScientificWorldJournal Review Article Hepatitis B virus (HBV) still remains a major global public health problem. One-half to one-third of the total HBV infected people died due to late detection of HBV. Serological antigen and viral HBV detections can help in the diagnosis, referral, and treatment of HBV. Available methods for HBV detection mostly used bulky instruments. Miniaturization of devices for HBV detection has been started by narrowing down the size of the devices. Several methods have also been proposed to increase the selectivity and sensitivity of the miniaturized methods, such as sandwich recognition of the biomarkers and the use of nano- to micro-sized materials. This review presents recent HBV detections in the last two decades from laboratory-based instruments towards microfluidic paper-based analytical devices (µPADs) for point-of-care testing (POCT) purposes. Early and routine analysis to detect HBV as early as possible could be achieved by POCT, especially for areas with limited access to a central laboratory and/or medical facilities. Hindawi 2021-02-26 /pmc/articles/PMC7937490/ /pubmed/33727897 http://dx.doi.org/10.1155/2021/6643573 Text en Copyright © 2021 Aulia A. Tyas et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tyas, Aulia A.
Raeni, Septi F.
Sakti, Setyawan P.
Sabarudin, Akhmad
Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices
title Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices
title_full Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices
title_fullStr Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices
title_full_unstemmed Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices
title_short Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices
title_sort recent advances of hepatitis b detection towards paper-based analytical devices
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937490/
https://www.ncbi.nlm.nih.gov/pubmed/33727897
http://dx.doi.org/10.1155/2021/6643573
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