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Left Ventricular Diastolic Dysfunction Is Associated With the Prevalence of Paroxysmal Atrial Fibrillation Determined on the Latest Echocardiographic Criteria

Background: The relationship between left ventricular diastolic dysfunction (LVDD) and paroxysmal atrial fibrillation (PAF) remains unclear because of a lack of standard measures to evaluate LVDD. Accordingly, we examined the association between the prevalence of PAF and each LVDD grade determined a...

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Autores principales: Akima, Takashi, Sekine, Katsutoshi, Yamaoka, Koki, Seki, Yuta, Nakajima, Kazuaki, Munakata, Masahito, Kanki, Hideaki, Akaishi, Makoto, Koyama, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Circulation Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937499/
https://www.ncbi.nlm.nih.gov/pubmed/33693192
http://dx.doi.org/10.1253/circrep.CR-20-0084
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author Akima, Takashi
Sekine, Katsutoshi
Yamaoka, Koki
Seki, Yuta
Nakajima, Kazuaki
Munakata, Masahito
Kanki, Hideaki
Akaishi, Makoto
Koyama, Takashi
author_facet Akima, Takashi
Sekine, Katsutoshi
Yamaoka, Koki
Seki, Yuta
Nakajima, Kazuaki
Munakata, Masahito
Kanki, Hideaki
Akaishi, Makoto
Koyama, Takashi
author_sort Akima, Takashi
collection PubMed
description Background: The relationship between left ventricular diastolic dysfunction (LVDD) and paroxysmal atrial fibrillation (PAF) remains unclear because of a lack of standard measures to evaluate LVDD. Accordingly, we examined the association between the prevalence of PAF and each LVDD grade determined according to the latest American Society of Echocardiography guidelines. Methods and Results: In all, 2,063 patients without persistent AF who underwent echocardiography at Saitama Municipal Hospital from July 2016 to June 2017 were included in the study. Patients were divided into LVDD 6 categories: No-LVDD (n=1,107), Borderline (n=392), Grade 1 (n=204), Indeterminate (n=62), Grade 2 (n=254), and Grade 3 (n=44). PAF was documented in 111 (10.0%), 81 (20.7%), 28 (13.7%), 6 (9.7%), 52 (20.5%), and 24 (54.5%) patients in the No-LVDD, Borderline, Grade 1, Indeterminate, Grade 2, and Grade 3 categories, respectively. PAF prevalence was higher in patients with Grade 3 LVDD across the whole study population. Subgroup analyses showed that the prevalence of PAF increased with increased LVDD grade in patients with reduced left ventricular ejection fraction. This relationship was significant in multivariate analysis including various patient characteristics. Conclusions: LVDD severity determined on the basis of the latest echocardiographic criteria was associated with the prevalence of PAF. The present findings shed light on the development of new therapeutic markers for PAF.
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spelling pubmed-79374992021-03-09 Left Ventricular Diastolic Dysfunction Is Associated With the Prevalence of Paroxysmal Atrial Fibrillation Determined on the Latest Echocardiographic Criteria Akima, Takashi Sekine, Katsutoshi Yamaoka, Koki Seki, Yuta Nakajima, Kazuaki Munakata, Masahito Kanki, Hideaki Akaishi, Makoto Koyama, Takashi Circ Rep Original article Background: The relationship between left ventricular diastolic dysfunction (LVDD) and paroxysmal atrial fibrillation (PAF) remains unclear because of a lack of standard measures to evaluate LVDD. Accordingly, we examined the association between the prevalence of PAF and each LVDD grade determined according to the latest American Society of Echocardiography guidelines. Methods and Results: In all, 2,063 patients without persistent AF who underwent echocardiography at Saitama Municipal Hospital from July 2016 to June 2017 were included in the study. Patients were divided into LVDD 6 categories: No-LVDD (n=1,107), Borderline (n=392), Grade 1 (n=204), Indeterminate (n=62), Grade 2 (n=254), and Grade 3 (n=44). PAF was documented in 111 (10.0%), 81 (20.7%), 28 (13.7%), 6 (9.7%), 52 (20.5%), and 24 (54.5%) patients in the No-LVDD, Borderline, Grade 1, Indeterminate, Grade 2, and Grade 3 categories, respectively. PAF prevalence was higher in patients with Grade 3 LVDD across the whole study population. Subgroup analyses showed that the prevalence of PAF increased with increased LVDD grade in patients with reduced left ventricular ejection fraction. This relationship was significant in multivariate analysis including various patient characteristics. Conclusions: LVDD severity determined on the basis of the latest echocardiographic criteria was associated with the prevalence of PAF. The present findings shed light on the development of new therapeutic markers for PAF. The Japanese Circulation Society 2020-10-24 /pmc/articles/PMC7937499/ /pubmed/33693192 http://dx.doi.org/10.1253/circrep.CR-20-0084 Text en Copyright © 2020, THE JAPANESE CIRCULATION SOCIETY This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original article
Akima, Takashi
Sekine, Katsutoshi
Yamaoka, Koki
Seki, Yuta
Nakajima, Kazuaki
Munakata, Masahito
Kanki, Hideaki
Akaishi, Makoto
Koyama, Takashi
Left Ventricular Diastolic Dysfunction Is Associated With the Prevalence of Paroxysmal Atrial Fibrillation Determined on the Latest Echocardiographic Criteria
title Left Ventricular Diastolic Dysfunction Is Associated With the Prevalence of Paroxysmal Atrial Fibrillation Determined on the Latest Echocardiographic Criteria
title_full Left Ventricular Diastolic Dysfunction Is Associated With the Prevalence of Paroxysmal Atrial Fibrillation Determined on the Latest Echocardiographic Criteria
title_fullStr Left Ventricular Diastolic Dysfunction Is Associated With the Prevalence of Paroxysmal Atrial Fibrillation Determined on the Latest Echocardiographic Criteria
title_full_unstemmed Left Ventricular Diastolic Dysfunction Is Associated With the Prevalence of Paroxysmal Atrial Fibrillation Determined on the Latest Echocardiographic Criteria
title_short Left Ventricular Diastolic Dysfunction Is Associated With the Prevalence of Paroxysmal Atrial Fibrillation Determined on the Latest Echocardiographic Criteria
title_sort left ventricular diastolic dysfunction is associated with the prevalence of paroxysmal atrial fibrillation determined on the latest echocardiographic criteria
topic Original article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937499/
https://www.ncbi.nlm.nih.gov/pubmed/33693192
http://dx.doi.org/10.1253/circrep.CR-20-0084
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