Cargando…

Early Identification of Alzheimer's Disease in Mouse Models: Application of Deep Neural Network Algorithm to Cognitive Behavioral Parameters

Alzheimer's disease (AD) is a worldwide burden. Diagnosis is complicated by the fact that AD is asymptomatic at an early stage. Studies using AD-modeled animals offer important and useful insights. Here, we classified mice with a high risk of AD at a preclinical stage by using only their behavi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sutoko, Stephanie, Masuda, Akira, Kandori, Akihiko, Sasaguri, Hiroki, Saito, Takashi, Saido, Takaomi C., Funane, Tsukasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937558/ https://www.ncbi.nlm.nih.gov/pubmed/33733064 http://dx.doi.org/10.1016/j.isci.2021.102198

Ejemplares similares

Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease
por: Funane, Tsukasa, et al.
Publicado: (2022)

Lesions in the right Rolandic operculum are associated with self-rating affective and apathetic depressive symptoms for post-stroke patients
por: Sutoko, Stephanie, et al.
Publicado: (2020)

Artificially-reconstructed brain images with stroke lesions from non-imaging data: modeling in categorized patients based on lesion occurrence and sparsity
por: Sutoko, Stephanie, et al.
Publicado: (2022)

Neuroinflammation in mouse models of Alzheimer's disease
por: Saito, Takashi, et al.
Publicado: (2018)

APP mouse models for Alzheimer's disease preclinical studies
por: Sasaguri, Hiroki, et al.
Publicado: (2017)

Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients
por: Nishimura, Ayako, et al.
Publicado: (2022)

A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide
por: Sato, Kaori, et al.
Publicado: (2021)

Adaptive algorithm utilizing acceptance rate for eliminating noisy epochs in block-design functional near-infrared spectroscopy data: application to study in attention deficit/hyperactivity disorder children
por: Sutoko, Stephanie, et al.
Publicado: (2018)

A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior
por: Ho, Hinze, et al.
Publicado: (2023)

Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged App(NL-G-F/NL-G-F) mice
por: Niikura, Ryo, et al.
Publicado: (2022)

Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease
por: Ito, Shingo, et al.
Publicado: (2023)

Hippocampal neural circuit connectivity alterations in an Alzheimer’s disease mouse model revealed by monosynaptic rabies virus tracing
por: Ye, Qiao, et al.
Publicado: (2022)

Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer’s disease
por: Islam, Anam, et al.
Publicado: (2023)

Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer’s Disease
por: Narukawa, Masataka, et al.
Publicado: (2020)

Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer’s Disease
por: Chen, Lingxuan, et al.
Publicado: (2018)

Microglia and CD206(+) border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease
por: Wu, Xiaoting, et al.
Publicado: (2021)

Exploring attentive task-based connectivity for screening attention deficit/hyperactivity disorder children: a functional near-infrared spectroscopy study
por: Sutoko, Stephanie, et al.
Publicado: (2019)

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease
por: Sakakibara, Yasufumi, et al.
Publicado: (2019)

Mental Condition Monitoring Based on Multimodality Biometry
por: Kiguchi, Masashi, et al.
Publicado: (2020)

Proposal of layered mental healthcare for mental well‐being
por: Kiguchi, Masashi, et al.
Publicado: (2021)

Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-K(ATP) channel pathway
por: Watamura, Naoto, et al.
Publicado: (2021)

Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation
por: Hashimoto, Shoko, et al.
Publicado: (2023)

Recent Advances in the Modeling of Alzheimer’s Disease
por: Sasaguri, Hiroki, et al.
Publicado: (2022)

Metabolism of amyloid β peptide and pathogenesis of Alzheimer’s disease
por: SAIDO, Takaomi C.
Publicado: (2013)

CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease
por: Park, Hanseul, et al.
Publicado: (2022)

Amelioration of Alzheimer’s Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model
por: Minamisawa, Mayumi, et al.
Publicado: (2021)

Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease
por: Izuo, Naotaka, et al.
Publicado: (2023)

Denoising of neuronal signal from mixed systemic low-frequency oscillation using peripheral measurement as noise regressor in near-infrared imaging
por: Sutoko, Stephanie, et al.
Publicado: (2019)

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID
por: Sasaguri, Hiroki, et al.
Publicado: (2018)

Atypical Dynamic-Connectivity Recruitment in Attention-Deficit/Hyperactivity Disorder Children: An Insight Into Task-Based Dynamic Connectivity Through an fNIRS Study
por: Sutoko, Stephanie, et al.
Publicado: (2020)

A high‐fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App (NL−F/NL−F) knock‐in mouse model
por: Mazzei, Guianfranco, et al.
Publicado: (2021)

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease
por: Hashimoto, Shoko, et al.
Publicado: (2018)

An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities
por: Watamura, Naoto, et al.
Publicado: (2022)

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide
por: Nilsson, Per, et al.
Publicado: (2014)

Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease
por: Saifullah, Md. Ali Bin, et al.
Publicado: (2020)

Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model
por: Nakazono, Tomoaki, et al.
Publicado: (2017)

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis
por: Sakakibara, Yasufumi, et al.
Publicado: (2018)

Impairment in novelty-promoted memory via behavioral tagging and capture before apparent memory loss in a knock-in model of Alzheimer’s disease
por: Broadbelt, Tabitha, et al.
Publicado: (2022)

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APP(NL-F) mouse model of Alzheimer disease
por: Wang, Hansen, et al.
Publicado: (2017)

Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the App(NL−F/NL−F) knock-in mouse model of Alzheimer’s disease
por: Andersson, Emelie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_c68a6np4nvkb7lbisi27j3lhc3