Safety and Antitumor Activity of Repeated ASP3026 Administration in Japanese Patients with Solid Tumors: A Phase I Study

BACKGROUND AND OBJECTIVE: Anaplastic lymphoma kinase gene rearrangements (ALKr) resulting in EML4–ALK proteins occur in a subset of solid tumors and are targeted by ALK inhibitors. Given the development of drug resistance to ALK inhibitors, ALK inhibitors with different kinase selectivity are requir...

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Detalles Bibliográficos
Autores principales: Ono, Akira, Murakami, Haruyasu, Seto, Takashi, Shimizu, Toshio, Watanabe, Sawori, Takeshita, Shigeru, Takeda, Kentaro, Toyoshima, Junko, Nagase, Itsuro, Bahceci, Erkut, Morishita, Maiko, Morita, Satoshi, Fukuoka, Masahiro, Nakagawa, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937589/
https://www.ncbi.nlm.nih.gov/pubmed/33331996
http://dx.doi.org/10.1007/s40268-020-00331-2

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