Cargando…

Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis

Aims: To evaluate the prognostic value of the preoperative lymphocyte-to-monocyte ratio (LMR) in patients who underwent cardiac surgery. Methods: Clinical data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. The optimal cutoff value of LMR was determined...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Zhuoming, Liang, Mengya, Wu, Huawei, Huang, Suiqing, Weng, Rennan, Hou, Jian, Wu, Zhongkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937643/
https://www.ncbi.nlm.nih.gov/pubmed/33693038
http://dx.doi.org/10.3389/fcvm.2021.639890
_version_ 1783661436026748928
author Zhou, Zhuoming
Liang, Mengya
Wu, Huawei
Huang, Suiqing
Weng, Rennan
Hou, Jian
Wu, Zhongkai
author_facet Zhou, Zhuoming
Liang, Mengya
Wu, Huawei
Huang, Suiqing
Weng, Rennan
Hou, Jian
Wu, Zhongkai
author_sort Zhou, Zhuoming
collection PubMed
description Aims: To evaluate the prognostic value of the preoperative lymphocyte-to-monocyte ratio (LMR) in patients who underwent cardiac surgery. Methods: Clinical data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. The optimal cutoff value of LMR was determined by X-tile software. The Cox proportional hazard model was applied for the identification of independent prognostic factors of 4-year mortality and survival curves were estimated using the Kaplan-Meier method. In order to balance the influence of potential confounding factors, a 1:1 propensity score matching (PSM) method was performed. Results: A total of 1,701 patients were included. The X-tile software indicated that the optimal cutoff value of the LMR for 4-year mortality was 3.58. After PSM, 489 pairs of score-matched patients were generated. The Cox proportional hazard model showed that patients with an LMR < 3.58 had a significantly higher 4-year mortality than patients with an LMR ≥ 3.58 in the entire cohort (HR = 1.925, 95%CI: 1.509–2.456, p < 0.001) and the PSM subset (HR = 1.568, 95%CI: 1.2–2.05, p = 0.001). The survival curves showed that patients with an LMR < 3.58 had a significant lower 4-year survival rate in the entire cohort (71.7 vs. 88.5%, p < 0.001) and the PSM subset (73.2 vs. 81.4%, p = 0.002). Conclusions: A lower LMR (<3.58) was associated with a higher risk of 4-year mortality and can serve as a prognostic predictor of the long-term mortality in cardiac surgery patients.
format Online
Article
Text
id pubmed-7937643
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79376432021-03-09 Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis Zhou, Zhuoming Liang, Mengya Wu, Huawei Huang, Suiqing Weng, Rennan Hou, Jian Wu, Zhongkai Front Cardiovasc Med Cardiovascular Medicine Aims: To evaluate the prognostic value of the preoperative lymphocyte-to-monocyte ratio (LMR) in patients who underwent cardiac surgery. Methods: Clinical data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. The optimal cutoff value of LMR was determined by X-tile software. The Cox proportional hazard model was applied for the identification of independent prognostic factors of 4-year mortality and survival curves were estimated using the Kaplan-Meier method. In order to balance the influence of potential confounding factors, a 1:1 propensity score matching (PSM) method was performed. Results: A total of 1,701 patients were included. The X-tile software indicated that the optimal cutoff value of the LMR for 4-year mortality was 3.58. After PSM, 489 pairs of score-matched patients were generated. The Cox proportional hazard model showed that patients with an LMR < 3.58 had a significantly higher 4-year mortality than patients with an LMR ≥ 3.58 in the entire cohort (HR = 1.925, 95%CI: 1.509–2.456, p < 0.001) and the PSM subset (HR = 1.568, 95%CI: 1.2–2.05, p = 0.001). The survival curves showed that patients with an LMR < 3.58 had a significant lower 4-year survival rate in the entire cohort (71.7 vs. 88.5%, p < 0.001) and the PSM subset (73.2 vs. 81.4%, p = 0.002). Conclusions: A lower LMR (<3.58) was associated with a higher risk of 4-year mortality and can serve as a prognostic predictor of the long-term mortality in cardiac surgery patients. Frontiers Media S.A. 2021-02-22 /pmc/articles/PMC7937643/ /pubmed/33693038 http://dx.doi.org/10.3389/fcvm.2021.639890 Text en Copyright © 2021 Zhou, Liang, Wu, Huang, Weng, Hou and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Zhou, Zhuoming
Liang, Mengya
Wu, Huawei
Huang, Suiqing
Weng, Rennan
Hou, Jian
Wu, Zhongkai
Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis
title Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis
title_full Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis
title_fullStr Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis
title_full_unstemmed Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis
title_short Preoperative Lymphocyte-to-Monocyte Ratio as a Prognostic Predictor of Long-Term Mortality in Cardiac Surgery Patients: A Propensity Score Matching Analysis
title_sort preoperative lymphocyte-to-monocyte ratio as a prognostic predictor of long-term mortality in cardiac surgery patients: a propensity score matching analysis
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937643/
https://www.ncbi.nlm.nih.gov/pubmed/33693038
http://dx.doi.org/10.3389/fcvm.2021.639890
work_keys_str_mv AT zhouzhuoming preoperativelymphocytetomonocyteratioasaprognosticpredictoroflongtermmortalityincardiacsurgerypatientsapropensityscorematchinganalysis
AT liangmengya preoperativelymphocytetomonocyteratioasaprognosticpredictoroflongtermmortalityincardiacsurgerypatientsapropensityscorematchinganalysis
AT wuhuawei preoperativelymphocytetomonocyteratioasaprognosticpredictoroflongtermmortalityincardiacsurgerypatientsapropensityscorematchinganalysis
AT huangsuiqing preoperativelymphocytetomonocyteratioasaprognosticpredictoroflongtermmortalityincardiacsurgerypatientsapropensityscorematchinganalysis
AT wengrennan preoperativelymphocytetomonocyteratioasaprognosticpredictoroflongtermmortalityincardiacsurgerypatientsapropensityscorematchinganalysis
AT houjian preoperativelymphocytetomonocyteratioasaprognosticpredictoroflongtermmortalityincardiacsurgerypatientsapropensityscorematchinganalysis
AT wuzhongkai preoperativelymphocytetomonocyteratioasaprognosticpredictoroflongtermmortalityincardiacsurgerypatientsapropensityscorematchinganalysis