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Loss of desmoglein-2 promotes gallbladder carcinoma progression and resistance to EGFR-targeted therapy through Src kinase activation

Gallbladder carcinoma (GBC) exhibits poor prognosis due to local recurrence, metastasis, and resistance to targeted therapies. Using clinicopathological analyses of GBC patients along with molecular in vitro and tumor in vivo analysis of GBC cells, we showed that reduction of Dsg2 expression was hig...

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Detalles Bibliográficos
Autores principales:	Lee, Sang-Hyun, Kim, Jin-Man, Lee, Dong Gwang, Lee, Jangwook, Park, Jong-Gil, Han, Tae-Su, Cho, Hyun-Soo, Cho, Young-Lai, Bae, Kwang-Hee, Park, Young-Jun, Lee, Seon-Jin, Lee, Moo-Seung, Huh, Yong-Min, Jo, Deog Yeon, Yun, Hwan-Jung, Jeon, Heung Jin, Kim, Nayoung, Joo, Mina, Kim, Jang-Seong, Lee, Hyo Jin, Min, Jeong-Ki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937683/ https://www.ncbi.nlm.nih.gov/pubmed/32989241 http://dx.doi.org/10.1038/s41418-020-00628-4

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