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The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge

After gaining experience conducting both auto and allografts in persons with hematological diseases in the HSCT programs in Puebla and Monterrey, México, this study outlines subsequent program autografting patients with autoimmune conditions. The first transplant in multiple sclerosis was conducted...

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Autores principales: Murrieta-Álvarez, Iván, Cantero-Fortiz, Yahveth, León-Peña, Andrés A., Olivares-Gazca, Juan C., Priesca-Marín, José Manuel, Ruiz-Delgado, Guillermo J., Gómez-De-León, Andrés, Gonzalez-Lopez, Elías Eugenio, Jaime-Pérez, José Carlos, Gómez-Almaguer, David, Ruiz-Argüelles, Guillermo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937693/
https://www.ncbi.nlm.nih.gov/pubmed/33692748
http://dx.doi.org/10.3389/fneur.2021.647425
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author Murrieta-Álvarez, Iván
Cantero-Fortiz, Yahveth
León-Peña, Andrés A.
Olivares-Gazca, Juan C.
Priesca-Marín, José Manuel
Ruiz-Delgado, Guillermo J.
Gómez-De-León, Andrés
Gonzalez-Lopez, Elías Eugenio
Jaime-Pérez, José Carlos
Gómez-Almaguer, David
Ruiz-Argüelles, Guillermo J.
author_facet Murrieta-Álvarez, Iván
Cantero-Fortiz, Yahveth
León-Peña, Andrés A.
Olivares-Gazca, Juan C.
Priesca-Marín, José Manuel
Ruiz-Delgado, Guillermo J.
Gómez-De-León, Andrés
Gonzalez-Lopez, Elías Eugenio
Jaime-Pérez, José Carlos
Gómez-Almaguer, David
Ruiz-Argüelles, Guillermo J.
author_sort Murrieta-Álvarez, Iván
collection PubMed
description After gaining experience conducting both auto and allografts in persons with hematological diseases in the HSCT programs in Puebla and Monterrey, México, this study outlines subsequent program autografting patients with autoimmune conditions. The first transplant in multiple sclerosis was conducted in Puebla on July 5, 2006. From 2015 we increased activity autografting persons with autoimmune conditions in the two campuses of the HSCT-México program: Puebla and Monterrey. By December 6, 2020, patient number 1,000 in the program was autografted. In our experience, a significant reduction in the expanded disability status scale score was achieved in all of the three phenotypes of the disease (from a median of 5.1 to 4.5 points), whereas the response rate (defined as a decrease of at least 0.5 of EDSS score regardless of baseline EDSS, or unchanged EDSS) was 83, 78, and 73% after 12 months in the relapsing-remitting, primary-progressive and secondary-progressive forms of multiple sclerosis, respectively. In addition to analyzing the viability, safety, and efficacy of our method, this study contributes new knowledge to the field of both stem cell transplantation and multiple sclerosis.
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spelling pubmed-79376932021-03-09 The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge Murrieta-Álvarez, Iván Cantero-Fortiz, Yahveth León-Peña, Andrés A. Olivares-Gazca, Juan C. Priesca-Marín, José Manuel Ruiz-Delgado, Guillermo J. Gómez-De-León, Andrés Gonzalez-Lopez, Elías Eugenio Jaime-Pérez, José Carlos Gómez-Almaguer, David Ruiz-Argüelles, Guillermo J. Front Neurol Neurology After gaining experience conducting both auto and allografts in persons with hematological diseases in the HSCT programs in Puebla and Monterrey, México, this study outlines subsequent program autografting patients with autoimmune conditions. The first transplant in multiple sclerosis was conducted in Puebla on July 5, 2006. From 2015 we increased activity autografting persons with autoimmune conditions in the two campuses of the HSCT-México program: Puebla and Monterrey. By December 6, 2020, patient number 1,000 in the program was autografted. In our experience, a significant reduction in the expanded disability status scale score was achieved in all of the three phenotypes of the disease (from a median of 5.1 to 4.5 points), whereas the response rate (defined as a decrease of at least 0.5 of EDSS score regardless of baseline EDSS, or unchanged EDSS) was 83, 78, and 73% after 12 months in the relapsing-remitting, primary-progressive and secondary-progressive forms of multiple sclerosis, respectively. In addition to analyzing the viability, safety, and efficacy of our method, this study contributes new knowledge to the field of both stem cell transplantation and multiple sclerosis. Frontiers Media S.A. 2021-02-22 /pmc/articles/PMC7937693/ /pubmed/33692748 http://dx.doi.org/10.3389/fneur.2021.647425 Text en Copyright © 2021 Murrieta-Álvarez, Cantero-Fortiz, León-Peña, Olivares-Gazca, Priesca-Marín, Ruiz-Delgado, Gómez-De-León, Gonzalez-Lopez, Jaime-Pérez, Gómez-Almaguer and Ruiz-Argüelles. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Murrieta-Álvarez, Iván
Cantero-Fortiz, Yahveth
León-Peña, Andrés A.
Olivares-Gazca, Juan C.
Priesca-Marín, José Manuel
Ruiz-Delgado, Guillermo J.
Gómez-De-León, Andrés
Gonzalez-Lopez, Elías Eugenio
Jaime-Pérez, José Carlos
Gómez-Almaguer, David
Ruiz-Argüelles, Guillermo J.
The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge
title The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge
title_full The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge
title_fullStr The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge
title_full_unstemmed The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge
title_short The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge
title_sort 1,000th transplant for multiple sclerosis and other autoimmune disorders at the hsct-méxico program: a myriad of experiences and knowledge
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937693/
https://www.ncbi.nlm.nih.gov/pubmed/33692748
http://dx.doi.org/10.3389/fneur.2021.647425
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