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Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction
We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and a significant increase in intracranial pressure...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937706/ https://www.ncbi.nlm.nih.gov/pubmed/33693018 http://dx.doi.org/10.3389/fmed.2021.629828 |
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| author | Xiang, Pan Xu, Xinmin Lu, Xin Gao, Lili Wang, Huizhu Li, Zhenpeng Xiong, Haofeng Li, Ruihong Xiong, Yanwen Pu, Lin Qin, Tian Jin, Fangfang Ren, Hongyu Li, Chuansheng Yang, Jing Zhang, Ming Gong, Jie Chen, Xiaoping Zheng, Han Tan, Jianbo Sun, Yao Zhao, Fei Hou, Xuexin Liu, Yufeng Guo, Hebing Hao, Jingjing Kan, Biao Zhou, Haijian Wang, Yajie Liu, Jingyuan |
| author_facet | Xiang, Pan Xu, Xinmin Lu, Xin Gao, Lili Wang, Huizhu Li, Zhenpeng Xiong, Haofeng Li, Ruihong Xiong, Yanwen Pu, Lin Qin, Tian Jin, Fangfang Ren, Hongyu Li, Chuansheng Yang, Jing Zhang, Ming Gong, Jie Chen, Xiaoping Zheng, Han Tan, Jianbo Sun, Yao Zhao, Fei Hou, Xuexin Liu, Yufeng Guo, Hebing Hao, Jingjing Kan, Biao Zhou, Haijian Wang, Yajie Liu, Jingyuan |
| author_sort | Xiang, Pan |
| collection | PubMed |
| description | We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and a significant increase in intracranial pressure developed in an adult coronavirus disease 2019 patient. The complete genome sequence of SARS-CoV-2 obtained from the cerebrospinal fluid indicates that SARS-CoV-2 can invade the central nervous system. In future, along with nervous system assessment, the pathogen genome detection and other indicators are needed for studying possible nervous system infection of SARS-CoV-2. |
| format | Online Article Text |
| id | pubmed-7937706 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79377062021-03-09 Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction Xiang, Pan Xu, Xinmin Lu, Xin Gao, Lili Wang, Huizhu Li, Zhenpeng Xiong, Haofeng Li, Ruihong Xiong, Yanwen Pu, Lin Qin, Tian Jin, Fangfang Ren, Hongyu Li, Chuansheng Yang, Jing Zhang, Ming Gong, Jie Chen, Xiaoping Zheng, Han Tan, Jianbo Sun, Yao Zhao, Fei Hou, Xuexin Liu, Yufeng Guo, Hebing Hao, Jingjing Kan, Biao Zhou, Haijian Wang, Yajie Liu, Jingyuan Front Med (Lausanne) Medicine We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and a significant increase in intracranial pressure developed in an adult coronavirus disease 2019 patient. The complete genome sequence of SARS-CoV-2 obtained from the cerebrospinal fluid indicates that SARS-CoV-2 can invade the central nervous system. In future, along with nervous system assessment, the pathogen genome detection and other indicators are needed for studying possible nervous system infection of SARS-CoV-2. Frontiers Media S.A. 2021-02-22 /pmc/articles/PMC7937706/ /pubmed/33693018 http://dx.doi.org/10.3389/fmed.2021.629828 Text en Copyright © 2021 Xiang, Xu, Lu, Gao, Wang, Li, Xiong, Li, Xiong, Pu, Qin, Jin, Ren, Li, Yang, Zhang, Gong, Chen, Zheng, Tan, Sun, Zhao, Hou, Liu, Guo, Hao, Kan, Zhou, Wang and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Medicine Xiang, Pan Xu, Xinmin Lu, Xin Gao, Lili Wang, Huizhu Li, Zhenpeng Xiong, Haofeng Li, Ruihong Xiong, Yanwen Pu, Lin Qin, Tian Jin, Fangfang Ren, Hongyu Li, Chuansheng Yang, Jing Zhang, Ming Gong, Jie Chen, Xiaoping Zheng, Han Tan, Jianbo Sun, Yao Zhao, Fei Hou, Xuexin Liu, Yufeng Guo, Hebing Hao, Jingjing Kan, Biao Zhou, Haijian Wang, Yajie Liu, Jingyuan Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction |
| title | Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction |
| title_full | Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction |
| title_fullStr | Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction |
| title_full_unstemmed | Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction |
| title_short | Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction |
| title_sort | case report: identification of sars-cov-2 in cerebrospinal fluid by ultrahigh-depth sequencing in a patient with coronavirus disease 2019 and neurological dysfunction |
| topic | Medicine |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937706/ https://www.ncbi.nlm.nih.gov/pubmed/33693018 http://dx.doi.org/10.3389/fmed.2021.629828 |
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