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Case Report: Metagenomics Next-Generation Sequencing Can Help Define the Best Therapeutic Strategy for Brain Abscesses Caused by Oral Pathogens

Brain abscesses are associated with an increased long-term risk of new seizures and increased mortality within several years after infection. Common microorganisms that cause brain abscesses include bacteria, fungi, and mycoplasma. We report a 75-year-old man with a brain abscess caused by Prevotell...

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Autores principales: Ma, Zhonghui, Yan, Su, Dong, Haoxin, Wang, Huifen, Luo, Yonggang, Wang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937709/
https://www.ncbi.nlm.nih.gov/pubmed/33693022
http://dx.doi.org/10.3389/fmed.2021.644130
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author Ma, Zhonghui
Yan, Su
Dong, Haoxin
Wang, Huifen
Luo, Yonggang
Wang, Xi
author_facet Ma, Zhonghui
Yan, Su
Dong, Haoxin
Wang, Huifen
Luo, Yonggang
Wang, Xi
author_sort Ma, Zhonghui
collection PubMed
description Brain abscesses are associated with an increased long-term risk of new seizures and increased mortality within several years after infection. Common microorganisms that cause brain abscesses include bacteria, fungi, and mycoplasma. We report a 75-year-old man with a brain abscess caused by Prevotella denticola, an oral pathogen. Based on the clinical condition, we suspected that the patient had a blood-borne brain abscess, and he received antibiotics and systemic supportive treatment. The patient developed shock for the second time after negative Gram-staining results. Metagenomics next-generation sequencing showed one strain from the oral microbiome, confirming our hypothesis, and targeted antibiotic treatment was administered quickly. Thus, we report a case in which genomic analysis was the critical factor in determining the best antimicrobial therapy for administration.
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spelling pubmed-79377092021-03-09 Case Report: Metagenomics Next-Generation Sequencing Can Help Define the Best Therapeutic Strategy for Brain Abscesses Caused by Oral Pathogens Ma, Zhonghui Yan, Su Dong, Haoxin Wang, Huifen Luo, Yonggang Wang, Xi Front Med (Lausanne) Medicine Brain abscesses are associated with an increased long-term risk of new seizures and increased mortality within several years after infection. Common microorganisms that cause brain abscesses include bacteria, fungi, and mycoplasma. We report a 75-year-old man with a brain abscess caused by Prevotella denticola, an oral pathogen. Based on the clinical condition, we suspected that the patient had a blood-borne brain abscess, and he received antibiotics and systemic supportive treatment. The patient developed shock for the second time after negative Gram-staining results. Metagenomics next-generation sequencing showed one strain from the oral microbiome, confirming our hypothesis, and targeted antibiotic treatment was administered quickly. Thus, we report a case in which genomic analysis was the critical factor in determining the best antimicrobial therapy for administration. Frontiers Media S.A. 2021-02-22 /pmc/articles/PMC7937709/ /pubmed/33693022 http://dx.doi.org/10.3389/fmed.2021.644130 Text en Copyright © 2021 Ma, Yan, Dong, Wang, Luo and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Ma, Zhonghui
Yan, Su
Dong, Haoxin
Wang, Huifen
Luo, Yonggang
Wang, Xi
Case Report: Metagenomics Next-Generation Sequencing Can Help Define the Best Therapeutic Strategy for Brain Abscesses Caused by Oral Pathogens
title Case Report: Metagenomics Next-Generation Sequencing Can Help Define the Best Therapeutic Strategy for Brain Abscesses Caused by Oral Pathogens
title_full Case Report: Metagenomics Next-Generation Sequencing Can Help Define the Best Therapeutic Strategy for Brain Abscesses Caused by Oral Pathogens
title_fullStr Case Report: Metagenomics Next-Generation Sequencing Can Help Define the Best Therapeutic Strategy for Brain Abscesses Caused by Oral Pathogens
title_full_unstemmed Case Report: Metagenomics Next-Generation Sequencing Can Help Define the Best Therapeutic Strategy for Brain Abscesses Caused by Oral Pathogens
title_short Case Report: Metagenomics Next-Generation Sequencing Can Help Define the Best Therapeutic Strategy for Brain Abscesses Caused by Oral Pathogens
title_sort case report: metagenomics next-generation sequencing can help define the best therapeutic strategy for brain abscesses caused by oral pathogens
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937709/
https://www.ncbi.nlm.nih.gov/pubmed/33693022
http://dx.doi.org/10.3389/fmed.2021.644130
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