CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool

A large number of studies in China and other countries have confirmed that circularHIPK3 (circHIPK3) plays an important role in the pathophysiological processes of various diseases. Through the action of sponge miRNA (miR), circHIPK3 regulates cell proliferation, differentiation, and migration, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Jiang, Wang, Baisheng, Bin, Xin, Xie, Changqing, Li, Bo, Liu, Ousheng, Tang, Zhangui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937734/
https://www.ncbi.nlm.nih.gov/pubmed/33693013
http://dx.doi.org/10.3389/fmed.2021.615417
_version_ 1783661454165016576
author Zhou, Jiang
Wang, Baisheng
Bin, Xin
Xie, Changqing
Li, Bo
Liu, Ousheng
Tang, Zhangui
author_facet Zhou, Jiang
Wang, Baisheng
Bin, Xin
Xie, Changqing
Li, Bo
Liu, Ousheng
Tang, Zhangui
author_sort Zhou, Jiang
collection PubMed
description A large number of studies in China and other countries have confirmed that circularHIPK3 (circHIPK3) plays an important role in the pathophysiological processes of various diseases. Through the action of sponge miRNA (miR), circHIPK3 regulates cell proliferation, differentiation, and migration, and plays a key role in disease processes. By referring to a large number of research reports, this article explores the specific functional role of circHIPK3 in fibrotic diseases, cancer, and other diseases. This review aims to clarify the role of circHIPK3 in disease processes in order to aid further studies into the specific pathogenesis and clinical diagnosis of various diseases and provide new ideas for treatments.
format Online
Article
Text
id pubmed-7937734
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79377342021-03-09 CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool Zhou, Jiang Wang, Baisheng Bin, Xin Xie, Changqing Li, Bo Liu, Ousheng Tang, Zhangui Front Med (Lausanne) Medicine A large number of studies in China and other countries have confirmed that circularHIPK3 (circHIPK3) plays an important role in the pathophysiological processes of various diseases. Through the action of sponge miRNA (miR), circHIPK3 regulates cell proliferation, differentiation, and migration, and plays a key role in disease processes. By referring to a large number of research reports, this article explores the specific functional role of circHIPK3 in fibrotic diseases, cancer, and other diseases. This review aims to clarify the role of circHIPK3 in disease processes in order to aid further studies into the specific pathogenesis and clinical diagnosis of various diseases and provide new ideas for treatments. Frontiers Media S.A. 2021-02-22 /pmc/articles/PMC7937734/ /pubmed/33693013 http://dx.doi.org/10.3389/fmed.2021.615417 Text en Copyright © 2021 Zhou, Wang, Bin, Xie, Li, Liu and Tang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhou, Jiang
Wang, Baisheng
Bin, Xin
Xie, Changqing
Li, Bo
Liu, Ousheng
Tang, Zhangui
CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool
title CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool
title_full CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool
title_fullStr CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool
title_full_unstemmed CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool
title_short CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool
title_sort circhipk3: key player in pathophysiology and potential diagnostic and therapeutic tool
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937734/
https://www.ncbi.nlm.nih.gov/pubmed/33693013
http://dx.doi.org/10.3389/fmed.2021.615417
work_keys_str_mv AT zhoujiang circhipk3keyplayerinpathophysiologyandpotentialdiagnosticandtherapeutictool
AT wangbaisheng circhipk3keyplayerinpathophysiologyandpotentialdiagnosticandtherapeutictool
AT binxin circhipk3keyplayerinpathophysiologyandpotentialdiagnosticandtherapeutictool
AT xiechangqing circhipk3keyplayerinpathophysiologyandpotentialdiagnosticandtherapeutictool
AT libo circhipk3keyplayerinpathophysiologyandpotentialdiagnosticandtherapeutictool
AT liuousheng circhipk3keyplayerinpathophysiologyandpotentialdiagnosticandtherapeutictool
AT tangzhangui circhipk3keyplayerinpathophysiologyandpotentialdiagnosticandtherapeutictool

Ejemplares similares