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In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review

Neoplasia of the cervix represents one of the most common cancers in women. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. The in-situ expression of several cytokines by uterine epithelial cells and b...

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Autores principales: Carrero, Yenddy N., Callejas, Diana E., Mosquera, Jesús A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937982/
https://www.ncbi.nlm.nih.gov/pubmed/33677234
http://dx.doi.org/10.1016/j.tranon.2021.101058
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author Carrero, Yenddy N.
Callejas, Diana E.
Mosquera, Jesús A.
author_facet Carrero, Yenddy N.
Callejas, Diana E.
Mosquera, Jesús A.
author_sort Carrero, Yenddy N.
collection PubMed
description Neoplasia of the cervix represents one of the most common cancers in women. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. The in-situ expression of several cytokines by uterine epithelial cells and by infiltrating leukocytes occurs during the cervical intraepithelial neoplasia and cervical cancer. Some of these cytokines can prevent and others can induce the progression of the neoplasm. The infiltrating leukocytes also produce cytokines and growth factors relate to angiogenesis, chemotaxis, and apoptosis capable of modulating the dysplasia progression. In this review we analyzed several interleukins with an inductive effect or blocking effect on the neoplastic progression. We also analyze the genetic polymorphism of some cytokines and their relationship with the risk of developing cervical neoplasia. In addition, we describe the leukocyte cells that infiltrate the cervical uterine tissue during the neoplasia and their effects on neoplasia progression.
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spelling pubmed-79379822021-03-17 In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review Carrero, Yenddy N. Callejas, Diana E. Mosquera, Jesús A. Transl Oncol Review Article (Critical Reviews in Oncology and Hematology) Neoplasia of the cervix represents one of the most common cancers in women. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. The in-situ expression of several cytokines by uterine epithelial cells and by infiltrating leukocytes occurs during the cervical intraepithelial neoplasia and cervical cancer. Some of these cytokines can prevent and others can induce the progression of the neoplasm. The infiltrating leukocytes also produce cytokines and growth factors relate to angiogenesis, chemotaxis, and apoptosis capable of modulating the dysplasia progression. In this review we analyzed several interleukins with an inductive effect or blocking effect on the neoplastic progression. We also analyze the genetic polymorphism of some cytokines and their relationship with the risk of developing cervical neoplasia. In addition, we describe the leukocyte cells that infiltrate the cervical uterine tissue during the neoplasia and their effects on neoplasia progression. Neoplasia Press 2021-03-04 /pmc/articles/PMC7937982/ /pubmed/33677234 http://dx.doi.org/10.1016/j.tranon.2021.101058 Text en © 2021 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article (Critical Reviews in Oncology and Hematology)
Carrero, Yenddy N.
Callejas, Diana E.
Mosquera, Jesús A.
In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review
title In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review
title_full In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review
title_fullStr In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review
title_full_unstemmed In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review
title_short In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review
title_sort in situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: review
topic Review Article (Critical Reviews in Oncology and Hematology)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937982/
https://www.ncbi.nlm.nih.gov/pubmed/33677234
http://dx.doi.org/10.1016/j.tranon.2021.101058
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