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Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis
Previous studies have reported the association between multiple genetic variants in the enamel-formation genes and the risk of dental caries with inconsistent results. We performed a systematic literature search of the PubMed, Cochrane Library, HuGE and Google Scholar databases for studies published...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938150/ https://www.ncbi.nlm.nih.gov/pubmed/33732050 http://dx.doi.org/10.1016/j.sjbs.2020.11.071 |
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author | Li, Xueyan Liu, Di Sun, Yang Yang, Jingyun Yu, Youcheng |
author_facet | Li, Xueyan Liu, Di Sun, Yang Yang, Jingyun Yu, Youcheng |
author_sort | Li, Xueyan |
collection | PubMed |
description | Previous studies have reported the association between multiple genetic variants in the enamel-formation genes and the risk of dental caries with inconsistent results. We performed a systematic literature search of the PubMed, Cochrane Library, HuGE and Google Scholar databases for studies published before March 21, 2020 and conducted meta-, gene-based and gene-cluster analysis on the association between genetic variants in the enamel-formation genes and the risk of dental caries. We identified 21 relevant publications including a total of 24 studies for analysis. The genetic variant rs17878486 in AMELX was significantly associated with dental caries risk (OR = 1.40, 95% CI: 1.02–1.93, P = 0.037). We found no significant association between the risk of dental caries with rs12640848 in ENAM (OR = 1.15, 95% CI: 0.88–1.52, P = 0.310), rs1784418 in MMP20 (OR = 1.07, 95% CI: 0.76–1.49, P = 0.702) and rs3796704 in ENAM (OR = 1.06, 95% CI: 0.96–1.17, P = 0.228). Gene-based analysis indicated that multiple genetic variants in AMELX showed joint association with the risk of dental caries (6 variants; P < 10(−5)), so did genetic variants in MMP13 (3 variants; P = 0.004), MMP2 (3 variants; P < 10(−5)), MMP20 (2 variants; P < 10(−5)) and MMP3 (2 variants; P < 10(−5)). The gene-cluster analysis indicated a significant association between the genetic variants in this enamel-formation gene cluster and the risk of dental caries (P < 10(−5)). The present meta-analysis revealed that genetic variant rs17878486 in AMELX was associated with dental caries, and multiple genetic variants in the enamel-formation genes jointly contributed to the risk of dental caries, supporting the role of genetic variants in the enamel-formation genes in the etiology of dental caries. |
format | Online Article Text |
id | pubmed-7938150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-79381502021-03-16 Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis Li, Xueyan Liu, Di Sun, Yang Yang, Jingyun Yu, Youcheng Saudi J Biol Sci Original Article Previous studies have reported the association between multiple genetic variants in the enamel-formation genes and the risk of dental caries with inconsistent results. We performed a systematic literature search of the PubMed, Cochrane Library, HuGE and Google Scholar databases for studies published before March 21, 2020 and conducted meta-, gene-based and gene-cluster analysis on the association between genetic variants in the enamel-formation genes and the risk of dental caries. We identified 21 relevant publications including a total of 24 studies for analysis. The genetic variant rs17878486 in AMELX was significantly associated with dental caries risk (OR = 1.40, 95% CI: 1.02–1.93, P = 0.037). We found no significant association between the risk of dental caries with rs12640848 in ENAM (OR = 1.15, 95% CI: 0.88–1.52, P = 0.310), rs1784418 in MMP20 (OR = 1.07, 95% CI: 0.76–1.49, P = 0.702) and rs3796704 in ENAM (OR = 1.06, 95% CI: 0.96–1.17, P = 0.228). Gene-based analysis indicated that multiple genetic variants in AMELX showed joint association with the risk of dental caries (6 variants; P < 10(−5)), so did genetic variants in MMP13 (3 variants; P = 0.004), MMP2 (3 variants; P < 10(−5)), MMP20 (2 variants; P < 10(−5)) and MMP3 (2 variants; P < 10(−5)). The gene-cluster analysis indicated a significant association between the genetic variants in this enamel-formation gene cluster and the risk of dental caries (P < 10(−5)). The present meta-analysis revealed that genetic variant rs17878486 in AMELX was associated with dental caries, and multiple genetic variants in the enamel-formation genes jointly contributed to the risk of dental caries, supporting the role of genetic variants in the enamel-formation genes in the etiology of dental caries. Elsevier 2021-03 2020-12-01 /pmc/articles/PMC7938150/ /pubmed/33732050 http://dx.doi.org/10.1016/j.sjbs.2020.11.071 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Li, Xueyan Liu, Di Sun, Yang Yang, Jingyun Yu, Youcheng Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis |
title | Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis |
title_full | Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis |
title_fullStr | Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis |
title_full_unstemmed | Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis |
title_short | Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis |
title_sort | association of genetic variants in enamel-formation genes with dental caries: a meta- and gene-cluster analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938150/ https://www.ncbi.nlm.nih.gov/pubmed/33732050 http://dx.doi.org/10.1016/j.sjbs.2020.11.071 |
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