Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM

IgG antibodies play a role in malaria immunity, but whether and how IgM protects from malaria and the biology of Plasmodium falciparum (Pf)–specific IgM B cells is unclear. In a Mali cohort spanning infants to adults, we conducted longitudinal analyses of Pf- and influenza-specific B cells. We found...

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Detalles Bibliográficos
Autores principales: Hopp, Christine S., Sekar, Padmapriya, Diouf, Ababacar, Miura, Kazutoyo, Boswell, Kristin, Skinner, Jeff, Tipton, Christopher M., Peterson, Mary E., Chambers, Michael J., Andrews, Sarah, Lu, Jinghua, Tan, Joshua, Li, Shanping, Doumbo, Safiatou, Kayentao, Kassoum, Ongoiba, Aissata, Traore, Boubacar, Portugal, Silvia, Sun, Peter D., Long, Carole, Koup, Richard A., Long, Eric O., McDermott, Adrian B., Crompton, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938365/
https://www.ncbi.nlm.nih.gov/pubmed/33661303
http://dx.doi.org/10.1084/jem.20200901

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