T Cell Protein Tyrosine Phosphatase in Osteoimmunology

Osteoimmunology highlights the two-way communication between bone and immune cells. T cell protein tyrosine phosphatase (TCPTP), also known as protein-tyrosine phosphatase non-receptor 2 (PTPN2), is an intracellular protein tyrosine phosphatase (PTP) essential in regulating immune responses and bone...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Ya-nan, Liu, Shiyue, Jia, Tingting, Feng, Yao, Zhang, Wenjing, Xu, Xin, Zhang, Dongjiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938726/
https://www.ncbi.nlm.nih.gov/pubmed/33692794
http://dx.doi.org/10.3389/fimmu.2021.620333
_version_ 1783661642372874240
author Wang, Ya-nan
Liu, Shiyue
Jia, Tingting
Feng, Yao
Zhang, Wenjing
Xu, Xin
Zhang, Dongjiao
author_facet Wang, Ya-nan
Liu, Shiyue
Jia, Tingting
Feng, Yao
Zhang, Wenjing
Xu, Xin
Zhang, Dongjiao
author_sort Wang, Ya-nan
collection PubMed
description Osteoimmunology highlights the two-way communication between bone and immune cells. T cell protein tyrosine phosphatase (TCPTP), also known as protein-tyrosine phosphatase non-receptor 2 (PTPN2), is an intracellular protein tyrosine phosphatase (PTP) essential in regulating immune responses and bone metabolism via dephosphorylating target proteins. Tcptp knockout in systemic or specific immune cells can seriously damage the immune function, resulting in bone metabolism disorders. This review provided fresh insights into the potential role of TCPTP in osteoimmunology. Overall, the regulation of osteoimmunology by TCPTP is extremely complicated. TCPTP negatively regulates macrophages activation and inflammatory factors secretion to inhibit bone resorption. TCPTP regulates T lymphocytes differentiation and T lymphocytes-related cytokines signaling to maintain bone homeostasis. TCPTP is also expected to regulate bone metabolism by targeting B lymphocytes under certain time and conditions. This review offers a comprehensive update on the roles of TCPTP in osteoimmunology, which can be a promising target for the prevention and treatment of inflammatory bone loss.
format Online
Article
Text
id pubmed-7938726
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79387262021-03-09 T Cell Protein Tyrosine Phosphatase in Osteoimmunology Wang, Ya-nan Liu, Shiyue Jia, Tingting Feng, Yao Zhang, Wenjing Xu, Xin Zhang, Dongjiao Front Immunol Immunology Osteoimmunology highlights the two-way communication between bone and immune cells. T cell protein tyrosine phosphatase (TCPTP), also known as protein-tyrosine phosphatase non-receptor 2 (PTPN2), is an intracellular protein tyrosine phosphatase (PTP) essential in regulating immune responses and bone metabolism via dephosphorylating target proteins. Tcptp knockout in systemic or specific immune cells can seriously damage the immune function, resulting in bone metabolism disorders. This review provided fresh insights into the potential role of TCPTP in osteoimmunology. Overall, the regulation of osteoimmunology by TCPTP is extremely complicated. TCPTP negatively regulates macrophages activation and inflammatory factors secretion to inhibit bone resorption. TCPTP regulates T lymphocytes differentiation and T lymphocytes-related cytokines signaling to maintain bone homeostasis. TCPTP is also expected to regulate bone metabolism by targeting B lymphocytes under certain time and conditions. This review offers a comprehensive update on the roles of TCPTP in osteoimmunology, which can be a promising target for the prevention and treatment of inflammatory bone loss. Frontiers Media S.A. 2021-02-22 /pmc/articles/PMC7938726/ /pubmed/33692794 http://dx.doi.org/10.3389/fimmu.2021.620333 Text en Copyright © 2021 Wang, Liu, Jia, Feng, Zhang, Xu and Zhang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Ya-nan
Liu, Shiyue
Jia, Tingting
Feng, Yao
Zhang, Wenjing
Xu, Xin
Zhang, Dongjiao
T Cell Protein Tyrosine Phosphatase in Osteoimmunology
title T Cell Protein Tyrosine Phosphatase in Osteoimmunology
title_full T Cell Protein Tyrosine Phosphatase in Osteoimmunology
title_fullStr T Cell Protein Tyrosine Phosphatase in Osteoimmunology
title_full_unstemmed T Cell Protein Tyrosine Phosphatase in Osteoimmunology
title_short T Cell Protein Tyrosine Phosphatase in Osteoimmunology
title_sort t cell protein tyrosine phosphatase in osteoimmunology
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938726/
https://www.ncbi.nlm.nih.gov/pubmed/33692794
http://dx.doi.org/10.3389/fimmu.2021.620333
work_keys_str_mv AT wangyanan tcellproteintyrosinephosphataseinosteoimmunology
AT liushiyue tcellproteintyrosinephosphataseinosteoimmunology
AT jiatingting tcellproteintyrosinephosphataseinosteoimmunology
AT fengyao tcellproteintyrosinephosphataseinosteoimmunology
AT zhangwenjing tcellproteintyrosinephosphataseinosteoimmunology
AT xuxin tcellproteintyrosinephosphataseinosteoimmunology
AT zhangdongjiao tcellproteintyrosinephosphataseinosteoimmunology

Ejemplares similares