Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived neurotrophic factor (BDNF) receptor that promotes neuronal plasticity and antidepre...

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Detalles Bibliográficos
Autores principales: Casarotto, Plinio C., Girych, Mykhailo, Fred, Senem M., Kovaleva, Vera, Moliner, Rafael, Enkavi, Giray, Biojone, Caroline, Cannarozzo, Cecilia, Sahu, Madhusmita Pryiadrashini, Kaurinkoski, Katja, Brunello, Cecilia A., Steinzeig, Anna, Winkel, Frederike, Patil, Sudarshan, Vestring, Stefan, Serchov, Tsvetan, Diniz, Cassiano R.A.F., Laukkanen, Liina, Cardon, Iseline, Antila, Hanna, Rog, Tomasz, Piepponen, Timo Petteri, Bramham, Clive R., Normann, Claus, Lauri, Sari E., Saarma, Mart, Vattulainen, Ilpo, Castrén, Eero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938888/
https://www.ncbi.nlm.nih.gov/pubmed/33606976
http://dx.doi.org/10.1016/j.cell.2021.01.034

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