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One-step sequence and structure-guided optimization of HIV-1 envelope gp140

Stabilization of the metastable envelope glycoprotein (Env) of HIV-1 is hypothesized to improve induction of broadly neutralizing antibodies. We improved the expression yield and stability of the HIV-1 envelope glycoprotein BG505SOSIP.664 gp140 by means of a previously described automated sequence a...

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Detalles Bibliográficos
Autores principales:	Malladi, Sameer Kumar, Schreiber, David, Pramanick, Ishika, Sridevi, Malavika Abhineshababu, Goldenzweig, Adi, Dutta, Somnath, Fleishman, Sarel Jacob, Varadarajan, Raghavan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939140/ https://www.ncbi.nlm.nih.gov/pubmed/33688632 http://dx.doi.org/10.1016/j.crstbi.2020.04.001

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