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Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report

We report on a patient with hypoxic-ischemic brain injury (HI-BI) who showed recovery from a minimally consciousness state over 6 years concurrent with recovery of an injured ascending reticular activating system (ARAS), which was demonstrated on diffusion tensor tractography (DTT). A 31-year-old fe...

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Autores principales: Jang, Sung Ho, Kim, Seong Ho, Seo, Jeong Pyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939211/
https://www.ncbi.nlm.nih.gov/pubmed/33655907
http://dx.doi.org/10.1097/MD.0000000000023933
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author Jang, Sung Ho
Kim, Seong Ho
Seo, Jeong Pyo
author_facet Jang, Sung Ho
Kim, Seong Ho
Seo, Jeong Pyo
author_sort Jang, Sung Ho
collection PubMed
description We report on a patient with hypoxic-ischemic brain injury (HI-BI) who showed recovery from a minimally consciousness state over 6 years concurrent with recovery of an injured ascending reticular activating system (ARAS), which was demonstrated on diffusion tensor tractography (DTT). A 31-year-old female patient, who suffered from HI-BI, showed impaired consciousness with a minimally conscious state: intermittently obeying simple motor tasks, such as “please grasp my hand.” Her consciousness showed recovery with the passage of time; rapid recovery was observed during the recent 2 years. In the upper ARAS, the neural connectivity to both the basal forebrain and prefrontal cortex had increased on 8-year DTT compared with 1.5-year DTT. In the lower dorsal and ventral ARAS, no significant change was observed between 1.5 and 8 years DTTs. Recovery of an injured ARAS was demonstrated in a patient who showed recovery from a minimally consciousness state over 6 years following HI-BI. Our results suggest the brain target areas for recovery of impaired awareness in patients with disorders of consciousness.
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spelling pubmed-79392112021-03-08 Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report Jang, Sung Ho Kim, Seong Ho Seo, Jeong Pyo Medicine (Baltimore) 6300 We report on a patient with hypoxic-ischemic brain injury (HI-BI) who showed recovery from a minimally consciousness state over 6 years concurrent with recovery of an injured ascending reticular activating system (ARAS), which was demonstrated on diffusion tensor tractography (DTT). A 31-year-old female patient, who suffered from HI-BI, showed impaired consciousness with a minimally conscious state: intermittently obeying simple motor tasks, such as “please grasp my hand.” Her consciousness showed recovery with the passage of time; rapid recovery was observed during the recent 2 years. In the upper ARAS, the neural connectivity to both the basal forebrain and prefrontal cortex had increased on 8-year DTT compared with 1.5-year DTT. In the lower dorsal and ventral ARAS, no significant change was observed between 1.5 and 8 years DTTs. Recovery of an injured ARAS was demonstrated in a patient who showed recovery from a minimally consciousness state over 6 years following HI-BI. Our results suggest the brain target areas for recovery of impaired awareness in patients with disorders of consciousness. Lippincott Williams & Wilkins 2021-03-05 /pmc/articles/PMC7939211/ /pubmed/33655907 http://dx.doi.org/10.1097/MD.0000000000023933 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 6300
Jang, Sung Ho
Kim, Seong Ho
Seo, Jeong Pyo
Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report
title Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report
title_full Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report
title_fullStr Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report
title_full_unstemmed Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report
title_short Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report
title_sort long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: a case report
topic 6300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939211/
https://www.ncbi.nlm.nih.gov/pubmed/33655907
http://dx.doi.org/10.1097/MD.0000000000023933
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