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Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report
We report on a patient with hypoxic-ischemic brain injury (HI-BI) who showed recovery from a minimally consciousness state over 6 years concurrent with recovery of an injured ascending reticular activating system (ARAS), which was demonstrated on diffusion tensor tractography (DTT). A 31-year-old fe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939211/ https://www.ncbi.nlm.nih.gov/pubmed/33655907 http://dx.doi.org/10.1097/MD.0000000000023933 |
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author | Jang, Sung Ho Kim, Seong Ho Seo, Jeong Pyo |
author_facet | Jang, Sung Ho Kim, Seong Ho Seo, Jeong Pyo |
author_sort | Jang, Sung Ho |
collection | PubMed |
description | We report on a patient with hypoxic-ischemic brain injury (HI-BI) who showed recovery from a minimally consciousness state over 6 years concurrent with recovery of an injured ascending reticular activating system (ARAS), which was demonstrated on diffusion tensor tractography (DTT). A 31-year-old female patient, who suffered from HI-BI, showed impaired consciousness with a minimally conscious state: intermittently obeying simple motor tasks, such as “please grasp my hand.” Her consciousness showed recovery with the passage of time; rapid recovery was observed during the recent 2 years. In the upper ARAS, the neural connectivity to both the basal forebrain and prefrontal cortex had increased on 8-year DTT compared with 1.5-year DTT. In the lower dorsal and ventral ARAS, no significant change was observed between 1.5 and 8 years DTTs. Recovery of an injured ARAS was demonstrated in a patient who showed recovery from a minimally consciousness state over 6 years following HI-BI. Our results suggest the brain target areas for recovery of impaired awareness in patients with disorders of consciousness. |
format | Online Article Text |
id | pubmed-7939211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-79392112021-03-08 Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report Jang, Sung Ho Kim, Seong Ho Seo, Jeong Pyo Medicine (Baltimore) 6300 We report on a patient with hypoxic-ischemic brain injury (HI-BI) who showed recovery from a minimally consciousness state over 6 years concurrent with recovery of an injured ascending reticular activating system (ARAS), which was demonstrated on diffusion tensor tractography (DTT). A 31-year-old female patient, who suffered from HI-BI, showed impaired consciousness with a minimally conscious state: intermittently obeying simple motor tasks, such as “please grasp my hand.” Her consciousness showed recovery with the passage of time; rapid recovery was observed during the recent 2 years. In the upper ARAS, the neural connectivity to both the basal forebrain and prefrontal cortex had increased on 8-year DTT compared with 1.5-year DTT. In the lower dorsal and ventral ARAS, no significant change was observed between 1.5 and 8 years DTTs. Recovery of an injured ARAS was demonstrated in a patient who showed recovery from a minimally consciousness state over 6 years following HI-BI. Our results suggest the brain target areas for recovery of impaired awareness in patients with disorders of consciousness. Lippincott Williams & Wilkins 2021-03-05 /pmc/articles/PMC7939211/ /pubmed/33655907 http://dx.doi.org/10.1097/MD.0000000000023933 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 6300 Jang, Sung Ho Kim, Seong Ho Seo, Jeong Pyo Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report |
title | Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report |
title_full | Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report |
title_fullStr | Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report |
title_full_unstemmed | Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report |
title_short | Long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: A case report |
title_sort | long-term recovery from a minimally responsive state with recovery of an injured ascending reticular activating system: a case report |
topic | 6300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939211/ https://www.ncbi.nlm.nih.gov/pubmed/33655907 http://dx.doi.org/10.1097/MD.0000000000023933 |
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