Cargando…

Obesity is associated with lower bacterial vaginosis prevalence in menopausal but not pre-menopausal women in a retrospective analysis of the Women’s Interagency HIV Study

The vaginal microbiota is known to impact women’s health, but the biological factors that influence the composition of the microbiota are not fully understood. We previously observed that levels of glycogen in the lumen of the vagina were higher in women that had a high body mass index (BMI). Vagina...

Descripción completa

Detalles Bibliográficos
Autores principales: Daubert, Elizabeth, Weber, Kathleen M., French, Audrey L., Seidman, Dominika, Michel, Katherine, Gustafson, Deborah, Murphy, Kerry, Muzny, Christina A., Alcaide, Maria, Sheth, Anandi, Adimora, Adaora A., Spear, Gregory T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939367/
https://www.ncbi.nlm.nih.gov/pubmed/33684141
http://dx.doi.org/10.1371/journal.pone.0248136
_version_ 1783661738270392320
author Daubert, Elizabeth
Weber, Kathleen M.
French, Audrey L.
Seidman, Dominika
Michel, Katherine
Gustafson, Deborah
Murphy, Kerry
Muzny, Christina A.
Alcaide, Maria
Sheth, Anandi
Adimora, Adaora A.
Spear, Gregory T.
author_facet Daubert, Elizabeth
Weber, Kathleen M.
French, Audrey L.
Seidman, Dominika
Michel, Katherine
Gustafson, Deborah
Murphy, Kerry
Muzny, Christina A.
Alcaide, Maria
Sheth, Anandi
Adimora, Adaora A.
Spear, Gregory T.
author_sort Daubert, Elizabeth
collection PubMed
description The vaginal microbiota is known to impact women’s health, but the biological factors that influence the composition of the microbiota are not fully understood. We previously observed that levels of glycogen in the lumen of the vagina were higher in women that had a high body mass index (BMI). Vaginal glycogen is thought to impact the composition of the vaginal microbiota. We therefore sought to determine if BMI was associated having or not having bacterial vaginosis (BV), as determined by the Amsel criteria. We also hypothesized that increased blood glucose levels could lead to the previously-observed higher vaginal glycogen levels and therefore investigated if hemoglobin A1c levels were associated with BV. We analyzed data from the Women’s Interagency HIV Study using multiple multivariable (GEE) logistic regression models to assess the relationship between BMI, BV and blood glucose. Women with a BMI >30 kg/m(2) (obese) had a lower rate (multivariable adjusted OR 0.87 (0.79–0.97), p = 0.009) of BV compared to the reference group (BMI 18.5–24.9 kg/m(2)). There was a significantly lower rate of BV in post-menopausal obese women compared to the post-menopausal reference group, but not in pre-menopausal women. HIV- post-menopausal obese women had a significantly lower rate of BV, but this was not seen in HIV+ post-menopausal obese women. Pre-menopausal women with a higher hemoglobin A1c (≥6.5%) had a significantly lower rate (multivariable adjusted OR 0.66 (0.49–0.91), p = 0.010) of BV compared to pre-menopausal women with normal hemoglobin A1c levels (<5.7%), but there was no difference in post-menopausal women. This study shows an inverse association of BMI with BV in post-menopausal women and hemoglobin A1c with BV in pre-menopausal women. Further studies are needed to confirm these relationships in other cohorts across different reproductive stages and to identify underlying mechanisms for these observed associations.
format Online
Article
Text
id pubmed-7939367
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-79393672021-03-18 Obesity is associated with lower bacterial vaginosis prevalence in menopausal but not pre-menopausal women in a retrospective analysis of the Women’s Interagency HIV Study Daubert, Elizabeth Weber, Kathleen M. French, Audrey L. Seidman, Dominika Michel, Katherine Gustafson, Deborah Murphy, Kerry Muzny, Christina A. Alcaide, Maria Sheth, Anandi Adimora, Adaora A. Spear, Gregory T. PLoS One Research Article The vaginal microbiota is known to impact women’s health, but the biological factors that influence the composition of the microbiota are not fully understood. We previously observed that levels of glycogen in the lumen of the vagina were higher in women that had a high body mass index (BMI). Vaginal glycogen is thought to impact the composition of the vaginal microbiota. We therefore sought to determine if BMI was associated having or not having bacterial vaginosis (BV), as determined by the Amsel criteria. We also hypothesized that increased blood glucose levels could lead to the previously-observed higher vaginal glycogen levels and therefore investigated if hemoglobin A1c levels were associated with BV. We analyzed data from the Women’s Interagency HIV Study using multiple multivariable (GEE) logistic regression models to assess the relationship between BMI, BV and blood glucose. Women with a BMI >30 kg/m(2) (obese) had a lower rate (multivariable adjusted OR 0.87 (0.79–0.97), p = 0.009) of BV compared to the reference group (BMI 18.5–24.9 kg/m(2)). There was a significantly lower rate of BV in post-menopausal obese women compared to the post-menopausal reference group, but not in pre-menopausal women. HIV- post-menopausal obese women had a significantly lower rate of BV, but this was not seen in HIV+ post-menopausal obese women. Pre-menopausal women with a higher hemoglobin A1c (≥6.5%) had a significantly lower rate (multivariable adjusted OR 0.66 (0.49–0.91), p = 0.010) of BV compared to pre-menopausal women with normal hemoglobin A1c levels (<5.7%), but there was no difference in post-menopausal women. This study shows an inverse association of BMI with BV in post-menopausal women and hemoglobin A1c with BV in pre-menopausal women. Further studies are needed to confirm these relationships in other cohorts across different reproductive stages and to identify underlying mechanisms for these observed associations. Public Library of Science 2021-03-08 /pmc/articles/PMC7939367/ /pubmed/33684141 http://dx.doi.org/10.1371/journal.pone.0248136 Text en © 2021 Daubert et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Daubert, Elizabeth
Weber, Kathleen M.
French, Audrey L.
Seidman, Dominika
Michel, Katherine
Gustafson, Deborah
Murphy, Kerry
Muzny, Christina A.
Alcaide, Maria
Sheth, Anandi
Adimora, Adaora A.
Spear, Gregory T.
Obesity is associated with lower bacterial vaginosis prevalence in menopausal but not pre-menopausal women in a retrospective analysis of the Women’s Interagency HIV Study
title Obesity is associated with lower bacterial vaginosis prevalence in menopausal but not pre-menopausal women in a retrospective analysis of the Women’s Interagency HIV Study
title_full Obesity is associated with lower bacterial vaginosis prevalence in menopausal but not pre-menopausal women in a retrospective analysis of the Women’s Interagency HIV Study
title_fullStr Obesity is associated with lower bacterial vaginosis prevalence in menopausal but not pre-menopausal women in a retrospective analysis of the Women’s Interagency HIV Study
title_full_unstemmed Obesity is associated with lower bacterial vaginosis prevalence in menopausal but not pre-menopausal women in a retrospective analysis of the Women’s Interagency HIV Study
title_short Obesity is associated with lower bacterial vaginosis prevalence in menopausal but not pre-menopausal women in a retrospective analysis of the Women’s Interagency HIV Study
title_sort obesity is associated with lower bacterial vaginosis prevalence in menopausal but not pre-menopausal women in a retrospective analysis of the women’s interagency hiv study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939367/
https://www.ncbi.nlm.nih.gov/pubmed/33684141
http://dx.doi.org/10.1371/journal.pone.0248136
work_keys_str_mv AT daubertelizabeth obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT weberkathleenm obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT frenchaudreyl obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT seidmandominika obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT michelkatherine obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT gustafsondeborah obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT murphykerry obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT muznychristinaa obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT alcaidemaria obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT shethanandi obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT adimoraadaoraa obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy
AT speargregoryt obesityisassociatedwithlowerbacterialvaginosisprevalenceinmenopausalbutnotpremenopausalwomeninaretrospectiveanalysisofthewomensinteragencyhivstudy