Cargando…

High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp90

Alzheimer's disease (AD) is characterized by neuronal loss and accumulation of β-amyloid-protein (Aβ) in the brain parenchyma. Sleep impairment is associated with AD and affects about 25–40% of patients in the mild-to-moderate stages of the disease. Sleep deprivation leads to increased Aβ produ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Noorani, Arshad Ali, Yamashita, Hitoshi, Gao, Yuan, Islam, Sadequl, Sun, Yang, Nakamura, Tomohisa, Enomoto, Hiroyuki, Zou, Kun, Michikawa, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939388/ https://www.ncbi.nlm.nih.gov/pubmed/33067321 http://dx.doi.org/10.1074/jbc.RA120.013845

Ejemplares similares

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
por: Yan, Yan, et al.
Publicado: (2017)

Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43
por: Tambini, Marc D., et al.
Publicado: (2020)

Inhibition of Heat Shock Protein 90 Prevents HIV Rebound
por: Joshi, Pheroze, et al.
Publicado: (2016)

Understanding the Functional Interplay between Mammalian Mitochondrial Hsp70 Chaperone Machine Components
por: Goswami, Arvind Vittal, et al.
Publicado: (2010)

Galectin 3–binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein
por: Seki, Tsuneyoshi, et al.
Publicado: (2020)

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
por: Nachman, Eliana, et al.
Publicado: (2020)

The Peroxisome Proliferator-activated Receptor γ (PPARγ) Controls Natural Protective Mechanisms against Lipid Peroxidation in Amyotrophic Lateral Sclerosis
por: Benedusi, Valeria, et al.
Publicado: (2012)

Expanding the Repertoire of Amyloid Polymorphs by Co-polymerization of Related Protein Precursors
por: Sarell, Claire J., et al.
Publicado: (2013)

Tumors with Nonfunctional Retinoblastoma Protein Are Killed by Reduced γ-Tubulin Levels
por: Ehlén, Åsa, et al.
Publicado: (2012)

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia
por: Neniskyte, Urte, et al.
Publicado: (2011)

Extracellular matrix components modulate different stages in β(2)-microglobulin amyloid formation
por: Benseny-Cases, Núria, et al.
Publicado: (2019)

Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies
por: Lautenschläger, Janin, et al.
Publicado: (2020)

Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and Neurotoxicity
por: Speretta, Elena, et al.
Publicado: (2012)

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicity in Vivo
por: Fluharty, Brian R., et al.
Publicado: (2013)

Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin
por: Townsend, David, et al.
Publicado: (2018)

Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation–inert complex
por: Wallin, Cecilia, et al.
Publicado: (2020)

β(2)-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes
por: Jakhria, Toral, et al.
Publicado: (2014)

ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production
por: Sano, Osamu, et al.
Publicado: (2016)

The serine protease HtrA1 cleaves misfolded transforming growth factor β–induced protein (TGFBIp) and induces amyloid formation
por: Poulsen, Ebbe Toftgaard, et al.
Publicado: (2019)

Novel Role for γ-Catenin in the Regulation of Cancer Cell Migration via the Induction of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1)
por: Sechler, Marybeth, et al.
Publicado: (2015)

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
por: Michno, Wojciech, et al.
Publicado: (2019)

Migfilin Protein Promotes Migration and Invasion in Human Glioma through Epidermal Growth Factor Receptor-mediated Phospholipase C-γ and STAT3 Protein Signaling Pathways
por: Ou, Yunwei, et al.
Publicado: (2012)

Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity
por: Miyamoto, Takashi, et al.
Publicado: (2016)

Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCF(cyclin F) E3 Ligase Machinery
por: Augustine, Tracy, et al.
Publicado: (2017)

The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43
por: Hicks, David A., et al.
Publicado: (2020)

Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE
por: Gao, Yuan, et al.
Publicado: (2023)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding
por: Pytowski, Lior, et al.
Publicado: (2021)

Bacterial Hsp90 Facilitates the Degradation of Aggregation-Prone Hsp70–Hsp40 Substrates
por: Fauvet, Bruno, et al.
Publicado: (2021)

Presenilin Deficiency Increases Susceptibility to Oxidative Damage in Fibroblasts
por: Zou, Kun, et al.
Publicado: (2022)

Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production
por: Suzuki, Ryota, et al.
Publicado: (2023)

Disruption of the ATP-binding Cassette B7 (ABTM-1/ABCB7) Induces Oxidative Stress and Premature Cell Death in Caenorhabditis elegans
por: González-Cabo, Pilar, et al.
Publicado: (2011)

HIV and HCV Cooperatively Promote Hepatic Fibrogenesis via Induction of Reactive Oxygen Species and NFκB
por: Lin, Wenyu, et al.
Publicado: (2011)

Hepatitis B Virus X Protein Regulates Hepatic Glucose Homeostasis via Activation of Inducible Nitric Oxide Synthase
por: Shin, Hye-Jun, et al.
Publicado: (2011)

Disruption of a Novel Krüppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Mellitus
por: Bonnefond, Amélie, et al.
Publicado: (2011)

Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes
por: Jay, Steven M., et al.
Publicado: (2011)

Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression
por: Gohil, Vishal M., et al.
Publicado: (2010)

The Legs at odd angles (Loa) Mutation in Cytoplasmic Dynein Ameliorates Mitochondrial Function in SOD1(G93A) Mouse Model for Motor Neuron Disease
por: El-Kadi, Ali Morsi, et al.
Publicado: (2010)

Bardet-Biedl Syndrome-associated Small GTPase ARL6 (BBS3) Functions at or near the Ciliary Gate and Modulates Wnt Signaling
por: Wiens, Cheryl J., et al.
Publicado: (2010)

Glutathione S-Transferase Omega 1 Activity Is Sufficient to Suppress Neurodegeneration in a Drosophila Model of Parkinson Disease
por: Kim, Kiyoung, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_58g1d29pavkei7rcp1iko9v74v