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High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp90

Alzheimer's disease (AD) is characterized by neuronal loss and accumulation of β-amyloid-protein (Aβ) in the brain parenchyma. Sleep impairment is associated with AD and affects about 25–40% of patients in the mild-to-moderate stages of the disease. Sleep deprivation leads to increased Aβ produ...

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Detalles Bibliográficos
Autores principales:	Noorani, Arshad Ali, Yamashita, Hitoshi, Gao, Yuan, Islam, Sadequl, Sun, Yang, Nakamura, Tomohisa, Enomoto, Hiroyuki, Zou, Kun, Michikawa, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939388/ https://www.ncbi.nlm.nih.gov/pubmed/33067321 http://dx.doi.org/10.1074/jbc.RA120.013845

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