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Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerization

Centrioles are key eukaryotic organelles that are responsible for the formation of cilia and flagella, and for organizing the microtubule network and the mitotic spindle in animals. Centriole assembly requires oligomerization of the essential protein spindle assembly abnormal 6 (SAS-6), which forms...

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Detalles Bibliográficos
Autores principales:	Busch, Julia M.C., Matsoukas, Minos-Timotheos, Musgaard, Maria, Spyroulias, Georgios A., Biggin, Philip C., Vakonakis, Ioannis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939395/ https://www.ncbi.nlm.nih.gov/pubmed/32873708 http://dx.doi.org/10.1074/jbc.RA120.014780

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