Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology

The tenovins are a frequently studied class of compounds capable of inhibiting sirtuin activity, which is thought to result in increased acetylation and protection of the tumor suppressor p53 from degradation. However, as we and other laboratories have shown previously, certain tenovins are also cap...

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Detalles Bibliográficos
Autores principales: Ladds, Marcus J. G.W., Popova, Gergana, Pastor-Fernández, Andrés, Kannan, Srinivasaraghavan, van Leeuwen, Ingeborg M.M., Håkansson, Maria, Walse, Björn, Tholander, Fredrik, Bhatia, Ravi, Verma, Chandra S., Lane, David P., Laín, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939445/
https://www.ncbi.nlm.nih.gov/pubmed/32900849
http://dx.doi.org/10.1074/jbc.RA119.012056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939445/
https://www.ncbi.nlm.nih.gov/pubmed/32900849
http://dx.doi.org/10.1074/jbc.RA119.012056

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