A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications

Abnormal changes of neuronal Tau protein, such as phosphorylation and aggregation, are considered hallmarks of cognitive deficits in Alzheimer's disease. Abnormal phosphorylation is thought to precede aggregation and therefore to promote aggregation, but the nature and extent of phosphorylation...

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Detalles Bibliográficos
Autores principales: Drepper, Friedel, Biernat, Jacek, Kaniyappan, Senthilvelrajan, Meyer, Helmut E., Mandelkow, Eva Maria, Warscheid, Bettina, Mandelkow, Eckhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939451/
https://www.ncbi.nlm.nih.gov/pubmed/33106314
http://dx.doi.org/10.1074/jbc.RA120.015882

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