Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions

Programmed cell death protein 1 (PD-1) is a critical inhibitory receptor that limits excessive T cell responses. Cancer cells have evolved to evade these immunoregulatory mechanisms by upregulating PD-1 ligands and preventing T cell–mediated anti-tumor responses. Consequently, therapeutic blockade o...

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Detalles Bibliográficos
Autores principales: Tocheva, Anna S., Peled, Michael, Strazza, Marianne, Adam, Kieran R., Lerrer, Shalom, Nayak, Shruti, Azoulay-Alfaguter, Inbar, Foster, Connor J.R., Philips, Elliot A., Neel, Benjamin G., Ueberheide, Beatrix, Mor, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939457/
https://www.ncbi.nlm.nih.gov/pubmed/33077516
http://dx.doi.org/10.1074/jbc.RA120.014745

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