PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression

Akt3 regulates mitochondrial content in endothelial cells through the inhibition of PGC-1α nuclear localization and is also required for angiogenesis. However, whether there is a direct link between mitochondrial function and angiogenesis is unknown. Here we show that Akt3 depletion in primary endot...

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Detalles Bibliográficos
Autores principales: Corum, Daniel G., Jenkins, Dorea P., Heslop, James A., Tallent, Lacey M., Beeson, Gyda C., Barth, Jeremy L., Schnellmann, Rick G., Muise-Helmericks, Robin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939459/
https://www.ncbi.nlm.nih.gov/pubmed/33087445
http://dx.doi.org/10.1074/jbc.RA120.013716

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