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Structural transitions in Orb2 prion-like domain relevant for functional aggregation in memory consolidation

The recent structural elucidation of ex vivo Drosophila Orb2 fibrils revealed a novel amyloid formed by interdigitated Gln and His residue side chains belonging to the prion-like domain. However, atomic-level details on the conformational transitions associated with memory consolidation remain unkno...

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Detalles Bibliográficos
Autores principales:	Oroz, Javier, Félix, Sara S., Cabrita, Eurico J., Laurents, Douglas V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939463/ https://www.ncbi.nlm.nih.gov/pubmed/33093173 http://dx.doi.org/10.1074/jbc.RA120.015211

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