The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2

The QT interval is a recording of cardiac electrical activity. Previous genome-wide association studies identified genetic variants that modify the QT interval upstream of LITAF (lipopolysaccharide-induced tumor necrosis factor-α factor), a protein encoding a regulator of endosomal trafficking. Howe...

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Detalles Bibliográficos
Autores principales: Turan, Nilüfer N., Moshal, Karni S., Roder, Karim, Baggett, Brett C., Kabakov, Anatoli Y., Dhakal, Saroj, Teramoto, Ryota, Chiang, David Yi-Eng, Zhong, Mingwang, Xie, An, Lu, Yichun, Dudley, Samuel C., MacRae, Calum A., Karma, Alain, Koren, Gideon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939464/
https://www.ncbi.nlm.nih.gov/pubmed/33093176
http://dx.doi.org/10.1074/jbc.RA120.015216

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