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Solvent accessibility changes in a Na(+)-dependent C(4)-dicarboxylate transporter suggest differential substrate effects in a multistep mechanism

The divalent anion sodium symporter (DASS) family (SLC13) plays critical roles in metabolic homeostasis, influencing many processes, including fatty acid synthesis, insulin resistance, and adiposity. DASS transporters catalyze the Na(+)-driven concentrative uptake of Krebs cycle intermediates and su...

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Detalles Bibliográficos
Autores principales:	Sampson, Connor D.D., Stewart, Matthew J., Mindell, Joseph A., Mulligan, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Membrane Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939474/ https://www.ncbi.nlm.nih.gov/pubmed/33087444 http://dx.doi.org/10.1074/jbc.RA120.013894

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