Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

Cells have evolved an elaborate DNA repair network to ensure complete and accurate DNA replication. Defects in these repair machineries can fuel genome instability and drive carcinogenesis while creating vulnerabilities that may be exploited in therapy. Here, we use nascent chromatin capture (NCC) p...

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Detalles Bibliográficos
Autores principales: Nakamura, Kyosuke, Kustatscher, Georg, Alabert, Constance, Hödl, Martina, Forne, Ignasi, Völker-Albert, Moritz, Satpathy, Shankha, Beyer, Tracey E., Mailand, Niels, Choudhary, Chunaram, Imhof, Axel, Rappsilber, Juri, Groth, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939521/
https://www.ncbi.nlm.nih.gov/pubmed/33450211
http://dx.doi.org/10.1016/j.molcel.2020.12.025

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