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CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion
Astrocyte-to-neuron conversion is a promising avenue for neuronal replacement therapy. Neurons are particularly dependent on mitochondrial function, but how well mitochondria adapt to the new fate is unknown. Here, we determined the comprehensive mitochondrial proteome of cortical astrocytes and neu...
Autores principales: | Russo, Gianluca L., Sonsalla, Giovanna, Natarajan, Poornemaa, Breunig, Christopher T., Bulli, Giorgia, Merl-Pham, Juliane, Schmitt, Sabine, Giehrl-Schwab, Jessica, Giesert, Florian, Jastroch, Martin, Zischka, Hans, Wurst, Wolfgang, Stricker, Stefan H., Hauck, Stefanie M., Masserdotti, Giacomo, Götz, Magdalena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939544/ https://www.ncbi.nlm.nih.gov/pubmed/33202244 http://dx.doi.org/10.1016/j.stem.2020.10.015 |
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