CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion

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Astrocyte-to-neuron conversion is a promising avenue for neuronal replacement therapy. Neurons are particularly dependent on mitochondrial function, but how well mitochondria adapt to the new fate is unknown. Here, we determined the comprehensive mitochondrial proteome of cortical astrocytes and neu...

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Detalles Bibliográficos
Autores principales: Russo, Gianluca L., Sonsalla, Giovanna, Natarajan, Poornemaa, Breunig, Christopher T., Bulli, Giorgia, Merl-Pham, Juliane, Schmitt, Sabine, Giehrl-Schwab, Jessica, Giesert, Florian, Jastroch, Martin, Zischka, Hans, Wurst, Wolfgang, Stricker, Stefan H., Hauck, Stefanie M., Masserdotti, Giacomo, Götz, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939544/
https://www.ncbi.nlm.nih.gov/pubmed/33202244
http://dx.doi.org/10.1016/j.stem.2020.10.015
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