Stress-induced nuclear condensation of NELF drives transcriptional downregulation

In response to stress, human cells coordinately downregulate transcription and translation of housekeeping genes. To downregulate transcription, the negative elongation factor (NELF) is recruited to gene promoters impairing RNA polymerase II elongation. Here we report that NELF rapidly forms nuclear...

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Detalles Bibliográficos
Autores principales: Rawat, Prashant, Boehning, Marc, Hummel, Barbara, Aprile-Garcia, Fernando, Pandit, Anwit S., Eisenhardt, Nathalie, Khavaran, Ashkan, Niskanen, Einari, Vos, Seychelle M., Palvimo, Jorma J., Pichler, Andrea, Cramer, Patrick, Sawarkar, Ritwick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939545/
https://www.ncbi.nlm.nih.gov/pubmed/33548202
http://dx.doi.org/10.1016/j.molcel.2021.01.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939545/
https://www.ncbi.nlm.nih.gov/pubmed/33548202
http://dx.doi.org/10.1016/j.molcel.2021.01.016

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