Cargando…

Stress-induced nuclear condensation of NELF drives transcriptional downregulation

In response to stress, human cells coordinately downregulate transcription and translation of housekeeping genes. To downregulate transcription, the negative elongation factor (NELF) is recruited to gene promoters impairing RNA polymerase II elongation. Here we report that NELF rapidly forms nuclear...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rawat, Prashant, Boehning, Marc, Hummel, Barbara, Aprile-Garcia, Fernando, Pandit, Anwit S., Eisenhardt, Nathalie, Khavaran, Ashkan, Niskanen, Einari, Vos, Seychelle M., Palvimo, Jorma J., Pichler, Andrea, Cramer, Patrick, Sawarkar, Ritwick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939545/ https://www.ncbi.nlm.nih.gov/pubmed/33548202 http://dx.doi.org/10.1016/j.molcel.2021.01.016

Ejemplares similares

Structure of paused transcription complex Pol II-DSIF-NELF
por: Vos, Seychelle M., et al.
Publicado: (2018)

Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-κB cistrome to reprogram the prostate cancer cell transcriptome
por: Malinen, Marjo, et al.
Publicado: (2017)

Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets
por: Toropainen, Sari, et al.
Publicado: (2016)

Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation
por: Lan, Chenyang, et al.
Publicado: (2023)

Molecular characterization of Drosophila NELF
por: Wu, Chwen-Huey, et al.
Publicado: (2005)

Transcriptional lockdown during acute proteotoxic stress
por: Sawarkar, Ritwick
Publicado: (2022)

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites
por: Paakinaho, Ville, et al.
Publicado: (2021)

NELF Potentiates Gene Transcription in the Drosophila Embryo
por: Wang, Xiaoling, et al.
Publicado: (2010)

Global SUMOylation on active chromatin is an acute heat stress response restricting transcription
por: Niskanen, Einari A., et al.
Publicado: (2015)

The NELF pausing checkpoint mediates the functional divergence of Cdk9
por: DeBerardine, Michael, et al.
Publicado: (2023)

Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells
por: Launonen, Kaisa-Mari, et al.
Publicado: (2021)

CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription
por: Laitem, Clélia, et al.
Publicado: (2015)

Negative Elongation Factor (NELF) Inhibits Premature Granulocytic Development in Zebrafish
por: Huang, Mengling, et al.
Publicado: (2022)

Tenth International Symposium on the Hsp90 chaperone machine: Switzerland, October 19-23, 2022
por: Edkins, Adrienne L., et al.
Publicado: (2023)

Structure of transcribing RNA polymerase II-nucleosome complex
por: Farnung, Lucas, et al.
Publicado: (2018)

Defining NELF-E RNA Binding in HIV-1 and Promoter-Proximal Pause Regions
por: Pagano, John M., et al.
Publicado: (2014)

NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma
por: Dang, Hien, et al.
Publicado: (2019)

Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF
por: Gorbovytska, Vladyslava, et al.
Publicado: (2022)

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction
por: Zhang, Fu-Ping, et al.
Publicado: (2019)

Mixture models and wavelet transforms reveal high confidence RNA-protein interaction sites in MOV10 PAR-CLIP data
por: Sievers, Cem, et al.
Publicado: (2012)

RNA polymerase II pausing factor NELF in CD8(+) T cells promotes antitumor immunity
por: Wu, Bogang, et al.
Publicado: (2022)

The negative elongation factor NELF promotes induced transcriptional response of Drosophila ecdysone-dependent genes
por: Mazina, Marina Yu., et al.
Publicado: (2021)

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis
por: Zhang, Jieqiong, et al.
Publicado: (2023)

Nucleosome-Chd1 structure and implications for chromatin remodelling
por: Farnung, Lucas, et al.
Publicado: (2017)

Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes
por: Stadelmayer, Bernd, et al.
Publicado: (2014)

Role of NELF-B in supporting epithelial-mesenchymal transition and cell proliferation during hepatocellular carcinoma progression
por: Ghouraba, Mennatallah Hani, et al.
Publicado: (2021)

DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II
por: Steurer, Barbara, et al.
Publicado: (2022)

NELFE promoted pancreatic cancer metastasis and the epithelial-to-mesenchymal transition by decreasing the stabilization of NDRG2 mRNA
por: Han, Lili, et al.
Publicado: (2019)

NELF‐A controls Drosophila healthspan by regulating heat‐shock protein‐mediated cellular protection and heterochromatin maintenance
por: Ngian, Zhen‐Kai, et al.
Publicado: (2021)

The RNA-Binding Protein NELFE Promotes Gastric Cancer Growth and Metastasis Through E2F2
por: Chen, Changyu, et al.
Publicado: (2021)

CREB3L1 and CREB3L2 control Golgi remodelling during decidualization of endometrial stromal cells
por: Pittari, Daniele, et al.
Publicado: (2022)

Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2
por: Schulze, Wiebke Manuela, et al.
Publicado: (2017)

Erratum to: NELF‐A controls Drosophila healthspan by regulating heat‐shock protein‐mediated cellular protection and heterochromatin maintenance
Publicado: (2022)

Genome-wide crosstalk between steroid receptors in breast and prostate cancers
por: Paakinaho, Ville, et al.
Publicado: (2021)

RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases
por: Battaglia, Sofia, et al.
Publicado: (2017)

Overexpression of NELFE contributes to gastric cancer progression via Wnt/β-catenin signaling-mediated activation of CSNK2B expression
por: Yu, Shijun, et al.
Publicado: (2021)

Complementary analysis of proteome‐wide proteomics reveals changes in RNA binding protein‐profiles during prostate cancer progression
por: Aikio, Erika, et al.
Publicado: (2023)

ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II
por: Ohe, Seina, et al.
Publicado: (2022)

Chicken genome analysis reveals novel genes encoding biotin-binding proteins related to avidin family
por: Niskanen, Einari A, et al.
Publicado: (2005)

CTR9, a Component of PAF Complex, Controls Elongation Block at the c-Fos Locus via Signal-Dependent Regulation of Chromatin-Bound NELF Dissociation
por: Yoo, Hyun-Seok, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_itj8bbosdnvm6bk1ajgs1tpfhe