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HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

Brain homeostasis is regulated by the viability and functionality of neurons. HAT (histone acetyltransferase) and HDAC (histone deacetylase) inhibitors have been applied to treat neurological deficits in humans; yet, the epigenetic regulation in neurodegeneration remains elusive. Mutations of HAT co...

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Detalles Bibliográficos
Autores principales:	Tapias, Alicia, Lázaro, David, Yin, Bo-Kun, Rasa, Seyed Mohammad Mahdi, Krepelova, Anna, Kelmer Sacramento, Erika, Grigaravicius, Paulius, Koch, Philipp, Kirkpatrick, Joanna, Ori, Alessandro, Neri, Francesco, Wang, Zhao-Qi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939550/ https://www.ncbi.nlm.nih.gov/pubmed/33594975 http://dx.doi.org/10.7554/eLife.61531

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