SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway

Macrophages promote an early host response to infection by releasing pro-inflammatory cytokines such as interleukin-1β (IL-1β), TNF, and IL-6. The bioactivity of IL-1β is classically dependent on NLRP3 inflammasome activation, which culminates in caspase-1 activation and pyroptosis. Recent studies s...

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Detalles Bibliográficos
Autores principales: Campbell, Grant R., To, Rachel K., Hanna, Jonathan, Spector, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939994/
https://www.ncbi.nlm.nih.gov/pubmed/33718825
http://dx.doi.org/10.1016/j.isci.2021.102295

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