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Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis

This study aimed to investigate the effect of maternal smoking during pregnancy (MSDP) on the risk of bone fractures in the offspring through a systematic review and meta-analysis. The PubMed, Web of Science, and Scopus databases were systematically searched for relevant articles published through J...

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Detalles Bibliográficos
Autores principales: Ayubi, Erfan, Safiri, Saeid, Mansori, Kamyar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Pediatric Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940084/
https://www.ncbi.nlm.nih.gov/pubmed/32023402
http://dx.doi.org/10.3345/cep.2019.01466
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author Ayubi, Erfan
Safiri, Saeid
Mansori, Kamyar
author_facet Ayubi, Erfan
Safiri, Saeid
Mansori, Kamyar
author_sort Ayubi, Erfan
collection PubMed
description This study aimed to investigate the effect of maternal smoking during pregnancy (MSDP) on the risk of bone fractures in the offspring through a systematic review and meta-analysis. The PubMed, Web of Science, and Scopus databases were systematically searched for relevant articles published through July 2019. According to heterogeneity, the pooled risk ratio (RR) and odds ratio (OR) and their corresponding 95% confidence interval (CI) were obtained using fixed or random effects models. The heterogeneity and quality of the included studies were assessed by the I-squared (I(2)) statistic and the Newcastle-Ottawa scale, respectively. Sensitivity analyses were performed to test the effect of MSDP misclassification on the results. The review of 842 search records yielded 5 studies including 8,746 mother-child pairs that were included in the meta-analysis. Pooling adjusted effect measures showed that MSDP was not associated with a later risk of bone fractures in the offspring (pooled RR, 1.15; 95% CI, 0.84–1.58; I(2)=66.8%; P=0.049). After the adjustment for misclassification, MSDP may be associated with a 27% increased risk of bone fracture (pooled OR, 1.27; 95% CI, 1.00–1.62; I(2)=0%; P=0.537). After the adjustment for misclassification, MSDP is associated with an increased risk of bone fractures among children whose mothers smoked during pregnancy.
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spelling pubmed-79400842021-03-15 Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis Ayubi, Erfan Safiri, Saeid Mansori, Kamyar Clin Exp Pediatr Review Article This study aimed to investigate the effect of maternal smoking during pregnancy (MSDP) on the risk of bone fractures in the offspring through a systematic review and meta-analysis. The PubMed, Web of Science, and Scopus databases were systematically searched for relevant articles published through July 2019. According to heterogeneity, the pooled risk ratio (RR) and odds ratio (OR) and their corresponding 95% confidence interval (CI) were obtained using fixed or random effects models. The heterogeneity and quality of the included studies were assessed by the I-squared (I(2)) statistic and the Newcastle-Ottawa scale, respectively. Sensitivity analyses were performed to test the effect of MSDP misclassification on the results. The review of 842 search records yielded 5 studies including 8,746 mother-child pairs that were included in the meta-analysis. Pooling adjusted effect measures showed that MSDP was not associated with a later risk of bone fractures in the offspring (pooled RR, 1.15; 95% CI, 0.84–1.58; I(2)=66.8%; P=0.049). After the adjustment for misclassification, MSDP may be associated with a 27% increased risk of bone fracture (pooled OR, 1.27; 95% CI, 1.00–1.62; I(2)=0%; P=0.537). After the adjustment for misclassification, MSDP is associated with an increased risk of bone fractures among children whose mothers smoked during pregnancy. Korean Pediatric Society 2020-02-05 /pmc/articles/PMC7940084/ /pubmed/32023402 http://dx.doi.org/10.3345/cep.2019.01466 Text en Copyright © 2021 by The Korean Pediatric Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ayubi, Erfan
Safiri, Saeid
Mansori, Kamyar
Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis
title Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis
title_full Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis
title_fullStr Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis
title_full_unstemmed Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis
title_short Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis
title_sort association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940084/
https://www.ncbi.nlm.nih.gov/pubmed/32023402
http://dx.doi.org/10.3345/cep.2019.01466
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