The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19

Many pathogenic viruses that affect man display species specificity, limiting the use of animal models. Studying viral biology and identifying potential treatments therefore benefits from the development of in vitro cell systems that closely mimic human physiology. In the current COVID-19 pandemic,...

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Detalles Bibliográficos
Autores principales: Geurts, Maarten H., van der Vaart, Jelte, Beumer, Joep, Clevers, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940129/
https://www.ncbi.nlm.nih.gov/pubmed/33691146
http://dx.doi.org/10.1016/j.stemcr.2020.11.009
Descripción
Sumario:Many pathogenic viruses that affect man display species specificity, limiting the use of animal models. Studying viral biology and identifying potential treatments therefore benefits from the development of in vitro cell systems that closely mimic human physiology. In the current COVID-19 pandemic, rapid scientific insights are of the utmost importance to limit its impact on public health and society. Organoids are emerging as versatile tools to progress the understanding of SARS-CoV-2 biology and to aid in the quest for novel treatments.

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