The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19

Many pathogenic viruses that affect man display species specificity, limiting the use of animal models. Studying viral biology and identifying potential treatments therefore benefits from the development of in vitro cell systems that closely mimic human physiology. In the current COVID-19 pandemic,...

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Detalles Bibliográficos
Autores principales: Geurts, Maarten H., van der Vaart, Jelte, Beumer, Joep, Clevers, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940129/
https://www.ncbi.nlm.nih.gov/pubmed/33691146
http://dx.doi.org/10.1016/j.stemcr.2020.11.009
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author Geurts, Maarten H.
van der Vaart, Jelte
Beumer, Joep
Clevers, Hans
author_facet Geurts, Maarten H.
van der Vaart, Jelte
Beumer, Joep
Clevers, Hans
author_sort Geurts, Maarten H.
collection PubMed
description Many pathogenic viruses that affect man display species specificity, limiting the use of animal models. Studying viral biology and identifying potential treatments therefore benefits from the development of in vitro cell systems that closely mimic human physiology. In the current COVID-19 pandemic, rapid scientific insights are of the utmost importance to limit its impact on public health and society. Organoids are emerging as versatile tools to progress the understanding of SARS-CoV-2 biology and to aid in the quest for novel treatments.
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spelling pubmed-79401292021-03-11 The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19 Geurts, Maarten H. van der Vaart, Jelte Beumer, Joep Clevers, Hans Stem Cell Reports Review Many pathogenic viruses that affect man display species specificity, limiting the use of animal models. Studying viral biology and identifying potential treatments therefore benefits from the development of in vitro cell systems that closely mimic human physiology. In the current COVID-19 pandemic, rapid scientific insights are of the utmost importance to limit its impact on public health and society. Organoids are emerging as versatile tools to progress the understanding of SARS-CoV-2 biology and to aid in the quest for novel treatments. Elsevier 2021-03-09 /pmc/articles/PMC7940129/ /pubmed/33691146 http://dx.doi.org/10.1016/j.stemcr.2020.11.009 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Geurts, Maarten H.
van der Vaart, Jelte
Beumer, Joep
Clevers, Hans
The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19
title The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19
title_full The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19
title_fullStr The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19
title_full_unstemmed The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19
title_short The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19
title_sort organoid platform: promises and challenges as tools in the fight against covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940129/
https://www.ncbi.nlm.nih.gov/pubmed/33691146
http://dx.doi.org/10.1016/j.stemcr.2020.11.009
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