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Hepatocyte nuclear factor 1 beta: A perspective in cancer
Hepatocyte nuclear factor 1 beta (HNF1 β/B) exists as a homeobox transcription factor having a vital role in the embryonic development of organs mainly liver, kidney and pancreas. Initially described as a gene causing maturity‐onset diabetes of the young (MODY), HNF1β expression deregulation and sin...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940219/ https://www.ncbi.nlm.nih.gov/pubmed/33580750 http://dx.doi.org/10.1002/cam4.3676 |
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author | Chandra, Shubhra Srinivasan, Srilakshmi Batra, Jyotsna |
author_facet | Chandra, Shubhra Srinivasan, Srilakshmi Batra, Jyotsna |
author_sort | Chandra, Shubhra |
collection | PubMed |
description | Hepatocyte nuclear factor 1 beta (HNF1 β/B) exists as a homeobox transcription factor having a vital role in the embryonic development of organs mainly liver, kidney and pancreas. Initially described as a gene causing maturity‐onset diabetes of the young (MODY), HNF1β expression deregulation and single nucleotide polymorphisms in HNF1β have now been associated with several tumours including endometrial, prostate, ovarian, hepatocellular, renal and colorectal cancers. Its function has been studied either as homodimer or heterodimer with HNF1α. In this review, the role of HNF1B in different cancers will be discussed along with the role of its splice variants, and its emerging role as a potential biomarker in cancer. |
format | Online Article Text |
id | pubmed-7940219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79402192021-03-16 Hepatocyte nuclear factor 1 beta: A perspective in cancer Chandra, Shubhra Srinivasan, Srilakshmi Batra, Jyotsna Cancer Med Cancer Biology Hepatocyte nuclear factor 1 beta (HNF1 β/B) exists as a homeobox transcription factor having a vital role in the embryonic development of organs mainly liver, kidney and pancreas. Initially described as a gene causing maturity‐onset diabetes of the young (MODY), HNF1β expression deregulation and single nucleotide polymorphisms in HNF1β have now been associated with several tumours including endometrial, prostate, ovarian, hepatocellular, renal and colorectal cancers. Its function has been studied either as homodimer or heterodimer with HNF1α. In this review, the role of HNF1B in different cancers will be discussed along with the role of its splice variants, and its emerging role as a potential biomarker in cancer. John Wiley and Sons Inc. 2021-02-13 /pmc/articles/PMC7940219/ /pubmed/33580750 http://dx.doi.org/10.1002/cam4.3676 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Biology Chandra, Shubhra Srinivasan, Srilakshmi Batra, Jyotsna Hepatocyte nuclear factor 1 beta: A perspective in cancer |
title | Hepatocyte nuclear factor 1 beta: A perspective in cancer |
title_full | Hepatocyte nuclear factor 1 beta: A perspective in cancer |
title_fullStr | Hepatocyte nuclear factor 1 beta: A perspective in cancer |
title_full_unstemmed | Hepatocyte nuclear factor 1 beta: A perspective in cancer |
title_short | Hepatocyte nuclear factor 1 beta: A perspective in cancer |
title_sort | hepatocyte nuclear factor 1 beta: a perspective in cancer |
topic | Cancer Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940219/ https://www.ncbi.nlm.nih.gov/pubmed/33580750 http://dx.doi.org/10.1002/cam4.3676 |
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