Cargando…
Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for biomedical research. However, they are immature, which is a barrier to modeling adult-onset cardiovascular disease. Here, we sought to develop a simple method that could drive cultured hiPSC-CMs toward...
Autores principales: | Knight, Walter E., Cao, Yingqiong, Lin, Ying-Hsi, Chi, Congwu, Bai, Betty, Sparagna, Genevieve C., Zhao, Yuanbiao, Du, Yanmei, Londono, Pilar, Reisz, Julie A., Brown, Benjamin C., Taylor, Matthew R.G., Ambardekar, Amrut V., Cleveland, Joseph C., McKinsey, Timothy A., Jeong, Mark Y., Walker, Lori A., Woulfe, Kathleen C., D'Alessandro, Angelo, Chatfield, Kathryn C., Xu, Hongyan, Bristow, Michael R., Buttrick, Peter M., Song, Kunhua |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940251/ https://www.ncbi.nlm.nih.gov/pubmed/33636116 http://dx.doi.org/10.1016/j.stemcr.2021.01.018 |
Ejemplares similares
-
High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling
por: Zhao, Yuanbiao, et al.
Publicado: (2015) -
Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy
por: Martin, Thomas G., et al.
Publicado: (2023) -
Elamipretide Improves Mitochondrial Function in the Failing Human Heart
por: Chatfield, Kathryn C., et al.
Publicado: (2019) -
Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine
por: Hooker, Jacob M., et al.
Publicado: (2017) -
HDAC6 modulates myofibril stiffness and diastolic function of the heart
por: Lin, Ying-Hsi, et al.
Publicado: (2022)