Spermatogonial Stem Cell Numbers Are Reduced by Transient Inhibition of GDNF Signaling but Restored by Self-Renewing Replication when Signaling Resumes

One cause of human male infertility is a scarcity of spermatogonial stem cells (SSCs) in testes with Sertoli cells that neither produce adequate amounts of GDNF nor form the Sertoli-Sertoli junctions that form the blood-testis barrier (BTB). These patients raise the issue of whether a pool of SSCs,...

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Detalles Bibliográficos
Autores principales: Parker, Nicole, Laychur, Andrew, Sukwani, Meena, Orwig, Kyle E., Oatley, Jon M., Zhang, Chao, Rutaganira, Florentine U., Shokat, Kevan, Wright, William W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940257/
https://www.ncbi.nlm.nih.gov/pubmed/33636117
http://dx.doi.org/10.1016/j.stemcr.2021.01.015

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