Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart

The cation channel transient receptor potential melastatin 4 (TRPM4) is a calcium-activated non-selective cation channel and acts in cardiomyocytes as a negative modulator of the L-type Ca(2+) influx. Global deletion of TRPM4 in the mouse led to increased cardiac contractility under β-adrenergic sti...

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Detalles Bibliográficos
Autores principales: Medert, Rebekka, Jungmann, Andreas, Hildebrand, Staffan, Busch, Martin, Grimm, Dirk, Flockerzi, Veit, Müller, Oliver J., Most, Patrick, Schumacher, Dagmar, Freichel, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940300/
https://www.ncbi.nlm.nih.gov/pubmed/33580817
http://dx.doi.org/10.1007/s00424-021-02521-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940300/
https://www.ncbi.nlm.nih.gov/pubmed/33580817
http://dx.doi.org/10.1007/s00424-021-02521-6

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