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Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart
The cation channel transient receptor potential melastatin 4 (TRPM4) is a calcium-activated non-selective cation channel and acts in cardiomyocytes as a negative modulator of the L-type Ca(2+) influx. Global deletion of TRPM4 in the mouse led to increased cardiac contractility under β-adrenergic sti...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940300/ https://www.ncbi.nlm.nih.gov/pubmed/33580817 http://dx.doi.org/10.1007/s00424-021-02521-6 |